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C57BI/6 Ola小鼠迷宫表现的昼夜差异。

Circadian differences in maze performance of C57BI/6 Ola mice.

作者信息

Hoffmann H J, Balschun D

机构信息

Institute of Neurobiology and Brain Research, Magdeburg, FRG.

出版信息

Behav Processes. 1992;27(2):77-83. doi: 10.1016/0376-6357(92)90017-8. Epub 2002 Jun 3.

DOI:10.1016/0376-6357(92)90017-8
PMID:24924493
Abstract

The diurnal expression of performance in a six-point alley-T-maze was studied in C57BI/6 Ola mice. Besides the error rate, the latency time for leaving the start box as well as the number of alleys entered per min were determined. From 08.00 hrs on, a group of 10 animals was investigated every four hours. Each group received one trial per day. Home cage activity was continously monitored over a 14-day period. The results revealed the development of a circadian rhythm of maze performance in the course of training, which became significant as from the 4th day. The best maze performance was observed in the middle of the dark phase, from 23.07 to 03.15 hrs. No indication of a direct relationship between home cage and ambulatory activity in the maze could be found.

摘要

在C57BI/6 Ola小鼠中研究了六点小巷T型迷宫中行为表现的昼夜表达。除了错误率外,还测定了离开起始箱的潜伏时间以及每分钟进入的小巷数量。从上午8点开始,每4小时对一组10只动物进行一次研究。每组每天接受一次试验。在14天的时间里持续监测笼内活动。结果显示,在训练过程中迷宫表现出现了昼夜节律,从第4天起变得显著。在黑暗阶段的中间,即23.07至03.15小时,观察到最佳的迷宫表现。未发现笼内活动与迷宫中自主活动之间存在直接关系的迹象。

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