Carter B S, Stewart J M
Department of Pediatrics, University of Colorado School of Medicine, Denver.
Clin Pediatr (Phila). 1989 Feb;28(2):81-5. doi: 10.1177/000992288902800205.
Valproic acid is an anticonvulsant that has been associated with open neural tube defects. We report a family in which the maternal use of valproic acid, and other anticonvulsants, during pregnancy resulted in different malformations in two siblings, one of which had a lipomyelomeningocele. The association of valproic acid and closed neural tube defects has not previously been reported. A brief review of the teratogenic effects of valproic acid is included as well as the implications for early surgical management of lipomyelomeningocele.
丙戊酸是一种与开放性神经管缺陷有关的抗惊厥药。我们报告了一个家庭，母亲在孕期使用丙戊酸及其他抗惊厥药，导致两个兄弟姐妹出现不同的畸形，其中一人患有脂肪脊髓脊膜膨出。丙戊酸与闭合性神经管缺陷的关联此前尚未见报道。本文还简要回顾了丙戊酸的致畸作用以及对脂肪脊髓脊膜膨出早期手术治疗的意义。
