丙戊酸有 teratogenic 性吗？ （注：“teratogenic”常见释义为“致畸的” ，这里由于不清楚具体语境，直接保留英文未翻译完整，可根据实际情况调整）
[Is valproic acid teratogenic?].
作者信息
Robert E, Robert J M, Lapras C
出版信息
Rev Neurol (Paris). 1983;139(6-7):445-7.
PMID:6412342
Abstract
In more than 7 000 cases of neonatal malformations processed up to 1982 in a regional computer register 71 infants had been born from epileptic mothers. A significantly higher than expected number of spina bifida aperta were observed in this group, related to the administration to the mother of the anti-epileptic agent valproic acid. A pathogenic hypothesis and a possible preventive procedure for this type of malformation are discussed.
摘要
在一个地区计算机登记处截至1982年处理的7000多例新生儿畸形病例中，有71名婴儿是癫痫母亲所生。在这组病例中观察到开放性脊柱裂的数量明显高于预期，这与母亲服用抗癫痫药物丙戊酸有关。本文讨论了这种畸形的致病假说和一种可能的预防措施。
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