Lamport D J, Chadwick H K, Dye L, Mansfield M W, Lawton C L
Institute of Psychological Sciences, University of Leeds, Woodhouse Lane, Leeds LS29JT, UK; School of Psychology and Clinical Language Sciences, Earley Gate, Whiteknights, University of Reading, Reading, UK.
Institute of Psychological Sciences, University of Leeds, Woodhouse Lane, Leeds LS29JT, UK.
Nutr Metab Cardiovasc Dis. 2014 Oct;24(10):1128-36. doi: 10.1016/j.numecd.2014.04.015. Epub 2014 May 14.
There has been no systematic investigation of the individual and combined effects of impaired glucose tolerance (IGT) and obesity on cognitive function in the absence of ageing. The aims were to examine the effects of IGT and increased waist circumference on cognitive function in ostensibly healthy adults, and to investigate whether a low glycaemic load (GL) breakfast can attenuate cognitive impairments in these populations.
Sixty five females aged 30-50 years were classified into one of four groups following waist circumference (WC) measurements and an oral glucose tolerance test: NGT/low WC (n = 25), NGT/high WC (n = 22), IGT/low WC (n = 9), IGT/high WC (n = 9). Memory, psychomotor and executive functions were examined 30 and 120 min after consuming low GL, high GL and water breakfasts according to a randomised, crossover, counterbalanced design. IGT was associated with impairment of verbal and spatial memory, and psychomotor function relative to females with NGT, independent of waist circumference. Increased waist circumference was associated with impairment of verbal memory and executive function relative to females with low WC, independent of IGT. Consumption of the LGL breakfast attenuated verbal memory impairment in the IGT/high WC group relative to the HGL breakfast and no energy control.
Increased central adiposity and abnormalities in glucose tolerance preceding type 2 diabetes can have demonstrable negative effects on cognitive function, even in ostensibly healthy, middle-aged females. The potential for GL manipulations to modulate glycaemic response and cognitive function in type 2 diabetes and obesity merits further investigation.
在未衰老的情况下，尚未对糖耐量受损（IGT）和肥胖对认知功能的个体及联合影响进行系统研究。目的是研究IGT和腰围增加对表面健康成年人认知功能的影响，并调查低血糖负荷（GL）早餐是否能减轻这些人群的认知障碍。
根据腰围测量和口服葡萄糖耐量试验，将65名30 - 50岁女性分为四组之一：正常糖耐量/低腰围（n = 25）、正常糖耐量/高腰围（n = 22）、IGT/低腰围（n = 9）、IGT/高腰围（n = 9）。根据随机、交叉、平衡设计，在食用低GL、高GL早餐和水后30分钟及120分钟检查记忆、精神运动和执行功能。与正常糖耐量女性相比，IGT与言语和空间记忆及精神运动功能受损相关，与腰围无关。与低腰围女性相比，腰围增加与言语记忆和执行功能受损相关，与IGT无关。与高GL早餐和无能量对照相比，食用低GL早餐减轻了IGT/高腰围组的言语记忆损害。
即使在表面健康的中年女性中，2型糖尿病之前中心性肥胖增加和糖耐量异常也会对认知功能产生明显负面影响。GL调节在2型糖尿病和肥胖中血糖反应及认知功能的潜力值得进一步研究。
