Sanchez-Aguadero Natalia, Garcia-Ortiz Luis, Patino-Alonso Maria C, Mora-Simon Sara, Gomez-Marcos Manuel A, Alonso-Dominguez Rosario, Sanchez-Salgado Benigna, Recio-Rodriguez Jose I
Primary Care Research Unit, The Alamedilla Health Centre, Castilla and León Health Service (SACYL), Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
Primary Care Research Unit, The Alamedilla Health Centre, Av. Comuneros N° 27, 37003, Salamanca, Spain.
Trials. 2016 Oct 24;17(1):516. doi: 10.1186/s13063-016-1649-x.
Postprandial glycaemic response affects cognitive and vascular function. The acute effect of breakfast glycaemic index on vascular parameters is not sufficiently known. Also, the influence of breakfasts with different glycaemic index on cognitive performance has been mostly studied in children and adolescents with varying results. Therefore, the purpose of this study is to analyse the postprandial effect of high and low glycaemic index breakfasts on vascular function and cognitive performance and their relationship with postprandial glycaemic response in healthy young adults.
METHODS/DESIGN: This is a crossover clinical trial targeting adults (aged 20-40 years, free from cardiovascular disease) selected by consecutive sampling at urban primary care health clinics in Salamanca (Spain). Each subject will complete three interventions with a washout period of one week: a control condition (consisting of water); a low glycaemic index breakfast (consisting of dark chocolate, walnuts, yogurt and an apple, with an overall glycaemic index of 29.4 and an energy contribution of 1489 kJ); and a high glycaemic index breakfast (consisting of bread, grape juice and strawberry jam, with an overall glycaemic index of 64.0 and an energy contribution of 1318 kJ). The postprandial effect will be assessed at 60 and 120 minutes from each breakfast including blood sampling and cognitive performance evaluations. Measurements of arterial stiffness and central haemodynamic parameters will be taken at -10, 0, 15, 30, 45, 60, 75, 90, 105 and 120 minutes.
The differences in postprandial glycaemic response due to breakfast glycaemic index could affect vascular parameters and cognitive performance with important applications and implications for the general population. This could provide necessary information for the establishment of new strategies in terms of nutritional education and work performance improvement.
ClinicalTrials.gov: NCT02616276 . Registered on 19 November 2015.
餐后血糖反应会影响认知和血管功能。早餐血糖指数对血管参数的急性影响尚不完全清楚。此外，不同血糖指数的早餐对认知表现的影响大多在儿童和青少年中进行了研究，结果各异。因此，本研究的目的是分析高血糖指数早餐和低血糖指数早餐对健康年轻成年人血管功能和认知表现的餐后影响，以及它们与餐后血糖反应的关系。
方法/设计：这是一项交叉临床试验，目标人群为通过在西班牙萨拉曼卡的城市初级保健健康诊所连续抽样选取的成年人（年龄在20 - 40岁之间，无心血管疾病）。每位受试者将完成三种干预措施，中间有一周的洗脱期：对照条件（仅饮水）；低血糖指数早餐（由黑巧克力、核桃、酸奶和一个苹果组成，总体血糖指数为29.4，能量贡献为1489千焦）；高血糖指数早餐（由面包、葡萄汁和草莓果酱组成，总体血糖指数为64.0，能量贡献为1318千焦）。在每次早餐后的60分钟和120分钟评估餐后影响，包括采血和认知表现评估。在 - 10、0、15、30、45、60、75、90、105和120分钟测量动脉僵硬度和中心血流动力学参数。
由于早餐血糖指数导致的餐后血糖反应差异可能会影响血管参数和认知表现，这对普通人群具有重要的应用价值和意义。这可以为制定营养教育和提高工作表现的新策略提供必要信息。
ClinicalTrials.gov：NCT02616276。于2015年11月19日注册。
