Sai Asari, Shimono Taro, Sakai Koji, Takeda Akitoshi, Shimada Hiroyuki, Tsukamoto Taro, Maeda Hiroko, Sakamoto Shinichi, Miki Yukio
Department of Radiology, Osaka City University Graduate School of Medicine Osaka, Japan.
J Magn Reson Imaging. 2014 Sep;40(3):649-54. doi: 10.1002/jmri.24396. Epub 2013 Oct 31.
To prospectively investigate brain temperature using MR diffusion-weighted imaging thermometry in multiple sclerosis (MS) patients and age-matched healthy controls, to examine comparisons of brain temperature between MS patients and healthy volunteers, and to examine correlations between brain temperature and disease duration and between brain temperature and Expanded Disability Status Scale (EDSS) in MS patients.
Thirteen MS patients and 13 age-matched healthy controls were examined using a 3.0 Tesla MR unit from January 2011 to February 2013. Brain temperature in each participant was measured using diffusion-weighted imaging-based MR thermometry of the lateral ventricles. Group comparisons of brain temperature between MS patients and healthy controls were performed using the Student's t-test. The determination of correlation between brain temperature in MS patients and disease duration, and between brain temperature and EDSS were performed using a Pearson's correlation coefficient test. For statistical analyses, values of P < 0.05 were considered statistically significant.
Median brain temperature was 35.81°C (range, 35.06-37.03°C) in MS patients, and 36.29°C (range, 35.51-37.89°C) in healthy controls representing a significant difference (P = 0.020). No significant correlation of both between brain temperature and disease duration and between brain temperature and EDSS were identified (r/P = -0.382/0.198, -0.026/0.933).
Brain temperature was significantly lower in MS patients than in healthy controls, probably representing decreased brain metabolism in MS patients.
前瞻性地利用磁共振扩散加权成像温度测量法研究多发性硬化症（MS）患者及年龄匹配的健康对照者的脑温，比较MS患者与健康志愿者的脑温，并研究MS患者脑温与病程以及脑温与扩展残疾状态量表（EDSS）之间的相关性。
2011年1月至2013年2月期间，使用3.0特斯拉磁共振设备对13例MS患者和13名年龄匹配的健康对照者进行检查。通过基于扩散加权成像的侧脑室磁共振温度测量法测量每位参与者的脑温。采用Student's t检验对MS患者与健康对照者的脑温进行组间比较。使用Pearson相关系数检验确定MS患者脑温与病程以及脑温与EDSS之间的相关性。进行统计分析时，P < 0.05的值被认为具有统计学意义。
MS患者的脑温中位数为35.81°C（范围为35.06 - 37.03°C），健康对照者为36.29°C（范围为35.51 - 37.89°C），差异有统计学意义（P = 0.020）。未发现脑温与病程以及脑温与EDSS之间存在显著相关性（r/P = -0.382/0.198，-0.026/0.933）。
MS患者的脑温显著低于健康对照者，这可能表明MS患者的脑代谢降低。
