Sparacia Gianvincenzo, Cannella Roberto, Lo Re Vincenzina, Mamone Giuseppe, Sakai Koji, Yamada Kei, Miraglia Roberto
Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT, Via Tricomi, 5, 90127, Palermo, Italy.
Department of Radiology, University of Palermo, Palermo, Italy.
Jpn J Radiol. 2018 May;36(5):324-330. doi: 10.1007/s11604-018-0729-0. Epub 2018 Mar 19.
To assess brain-core temperature of end-stage liver disease patients undergoing orthotopic liver transplantation (OLT) using a temperature measurement technique based on the apparent diffusion coefficient of the cerebrospinal fluid in the lateral ventricles.
The study group was composed of 19 patients with a model for end-stage liver disease (MELD) score of 23.7 who underwent MR imaging before and after OLT. MR imaging studies were performed with a 1.5T MR scanner. Brain-core temperature (T: °C) was calculated using the following equation from the apparent diffusion coefficient (D) of the cerebrospinal fluid in the lateral ventricles: [Formula: see text] measured with a DWI sequence (b value 1000 s/mm). We compared brain-core temperature of all patients before and after OLT.
Brain-core temperature measurements were successfully taken in all patients before and after OLT. The measured brain-core temperature mean ± standard deviation was 38.67 ± 1.76 °C before OLT and 38.60 ± 0.99 °C after OLT, showing no significant difference (P = 0.643).
Brain-core temperature was stable in patients undergoing OLT. DWI thermometry may provide a supplementary brain biomarker to confirm that cerebral blood flow and metabolism are stable in patients undergoing OLT.
采用基于侧脑室脑脊液表观扩散系数的温度测量技术，评估接受原位肝移植（OLT）的终末期肝病患者的脑核心温度。
研究组由19例终末期肝病模型（MELD）评分为23.7的患者组成，这些患者在OLT前后均接受了磁共振成像（MR成像）。使用1.5T MR扫描仪进行MR成像研究。脑核心温度（T：°C）根据侧脑室脑脊液的表观扩散系数（D），通过以下公式计算得出：[公式：见原文]，使用扩散加权成像（DWI）序列（b值1000 s/mm²）进行测量。我们比较了所有患者OLT前后的脑核心温度。
所有患者在OLT前后均成功进行了脑核心温度测量。测量的脑核心温度平均值±标准差在OLT前为38.67±1.76°C，OLT后为38.60±0.99°C，差异无统计学意义（P = 0.643）。
接受OLT的患者脑核心温度稳定。DWI测温法可能提供一种补充性脑生物标志物，以确认接受OLT的患者脑血流量和代谢稳定。
