主动脉中Toll样受体4水平与动脉粥样硬化严重程度之间的关系。
Relationship between toll-like receptor 4 levels in aorta and severity of atherosclerosis.
作者信息
Xing Shanshan, Zheng Fei, Zhang Wei, Wang Dong, Xing Qichong
机构信息
Department of Internal Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Cardiology, Qianfoshan Hospital, Shandong University, Jinan, China.
出版信息
J Int Med Res. 2014 Aug;42(4):958-65. doi: 10.1177/0300060514534645. Epub 2014 Jun 12.
OBJECTIVE
To investigate the relationship between levels of toll-like receptor 4 (TLR4) protein in aortic tissue and the severity of atherosclerosis in patients undergoing coronary artery bypass graft (CABG) surgery.
METHODS
Samples of ascending aorta and renal artery were collected from patients undergoing CABG surgery or kidney donation, respectively. TLR4 levels were determined by immunohistochemistry. Coronary angiography was performed to determine atherosclerosis severity via Gensini score.
RESULTS
TLR4 was present at high levels in aortic tissues from patients (n = 46), and was absent from renal artery tissue (controls; n = 11). There was a significant positive correlation between Gensini score and TLR4 level in the patient group.
CONCLUSIONS
TLR4 may play an important role in atherosclerosis and could be a potential therapeutic target for treatment of coronary artery disease. Discarded aortic tissue obtained during CABG surgery provides a new approach to the study of the pathogenesis of atherosclerosis.
目的
探讨冠状动脉旁路移植术（CABG）患者主动脉组织中Toll样受体4（TLR4）蛋白水平与动脉粥样硬化严重程度之间的关系。
方法
分别从接受CABG手术的患者或肾移植供体中采集升主动脉和肾动脉样本。通过免疫组织化学法测定TLR4水平。进行冠状动脉造影，通过Gensini评分确定动脉粥样硬化的严重程度。
结果
患者（n = 46）主动脉组织中TLR4水平较高，而肾动脉组织（对照组；n = 11）中未检测到TLR4。患者组中Gensini评分与TLR4水平之间存在显著正相关。
结论
TLR4可能在动脉粥样硬化中起重要作用，可能成为治疗冠状动脉疾病的潜在治疗靶点。CABG手术中废弃的主动脉组织为动脉粥样硬化发病机制的研究提供了新途径。
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