Min Y, Djahanbakhch O, Hutchinson J, Bhullar A S, Raveendran M, Hallot A, Eram S, Namugere I, Nateghian S, Ghebremeskel K
Lipidomics and Nutrition Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, UK.
Diabet Med. 2014 Nov;31(11):1331-40. doi: 10.1111/dme.12524. Epub 2014 Jun 28.
To test if docosahexaenoic acid-enriched fish oil supplementation rectifies red cell membrane lipid anomaly in pregnant women with Type 2 diabetes and their neonates, and alters fetal body composition.
Women with Type 2 diabetes (n = 88; 41 fish oil, 47 placebo) and healthy women (n = 85; 45 fish oil, 40 placebo) were supplemented from the first trimester until delivery. Blood fatty acid composition, fetal biometric and neonatal anthropometric measurements were assessed.
A total of 117 women completed the trial. The women with Type 2 diabetes who took fish oil compared with those who received placebo had higher percentage of docosahexaenoic acid in red cell phosphatidylethanolamine in the third trimester (12.0% vs. 8.9%, P = 0.000) and at delivery (10.7% vs. 7.4%, P = 0.001). Similarly, the neonates of the women with Type 2 diabetes supplemented with the fish oil had increased docosahexaenoic acid in the red cell phosphatidylethanolamine (9.2% vs. 7.7%, P = 0.027) and plasma phosphatidylcholine (6.1% vs. 4.7%, P = 0.020). Docosahexaenoic acid-rich fish oil had no effect on the body composition of the fetus and neonates of the women with Type 2 diabetes.
A daily dose of 600 mg of docosahexaenoic acid was effective in ameliorating red cell membrane docosahexaenoic acid anomaly in pregnant women with Type 2 diabetes and neonates, and in preventing the decline of maternal docosahexaenoic acid during pregnancy. We suggest that the provision of docosahexaenoic acid supplement should be integrated in the antenatal care of pregnant women with Type 2 diabetes.
测试补充富含二十二碳六烯酸的鱼油是否能纠正2型糖尿病孕妇及其新生儿的红细胞膜脂质异常，并改变胎儿身体成分。
2型糖尿病女性（n = 88；41人服用鱼油，47人服用安慰剂）和健康女性（n = 85；45人服用鱼油，40人服用安慰剂）从孕早期开始补充直至分娩。评估血液脂肪酸组成、胎儿生物测量和新生儿人体测量数据。
共有117名女性完成试验。与服用安慰剂的2型糖尿病女性相比，服用鱼油的女性在孕晚期红细胞磷脂酰乙醇胺中二十二碳六烯酸的百分比更高（12.0%对8.9%，P = 0.000），分娩时也是如此（10.7%对7.4%，P = 0.001）。同样，补充鱼油的2型糖尿病女性的新生儿红细胞磷脂酰乙醇胺中二十二碳六烯酸增加（9.2%对7.7%，P = 0.027），血浆磷脂酰胆碱中也是如此（6.1%对4.7%，P = 0.020）。富含二十二碳六烯酸的鱼油对2型糖尿病女性的胎儿和新生儿的身体成分没有影响。
每日剂量600毫克的二十二碳六烯酸可有效改善2型糖尿病孕妇及其新生儿红细胞膜二十二碳六烯酸异常，并防止孕期母体二十二碳六烯酸下降。我们建议在2型糖尿病孕妇的产前护理中应加入二十二碳六烯酸补充剂。
