回顾性描述性研究口服唑类抗真菌药物在斑贴试验阴性的头颈部为主的特应性皮炎患者中的应用。
A retrospective descriptive study of oral azole antifungal agents in patients with patch test-negative head and neck predominant atopic dermatitis.
机构信息
Division of Dermatology, Ohio State University College of Medicine, Columbus, Ohio; Ohio State University College of Medicine, Columbus, Ohio.
Ohio State University College of Medicine, Columbus, Ohio.
出版信息
J Am Acad Dermatol. 2014 Sep;71(3):480-3. doi: 10.1016/j.jaad.2014.04.045. Epub 2014 Jun 10.
BACKGROUND
Head and neck dermatitis is a subtype of atopic dermatitis driven by Malassezia yeast.
OBJECTIVE
We sought to evaluate the response of these patients to systemic azole antifungals.
METHODS
We queried the electronic medical records from our institution for patients that were referred for allergy patch testing, were ultimately given the diagnosis of head and neck dermatitis, and were treated with oral azole antifungals over a 2-year period.
RESULTS
Twenty-four patients met inclusion criteria and were analyzed. Most patients noted their characteristic flare beginning during their teenage, young adult, or adult years. All were noted to have some involvement of the head and neck, and 17 responded to treatment. The mean time taking an azole antifungal medication was 8 months, with a mean overall follow-up of 10 months.
LIMITATIONS
This was a retrospective descriptive study, from a single institution, of a limited number of patients, and did not use a validated scoring system.
CONCLUSION
Itraconazole and other azole antifungals were an effective treatment for more than two-thirds of adult patients with head and neck predominant atopic dermatitis.
背景
头部和颈部皮炎是一种特应性皮炎亚型，由马拉色酵母引起。
目的
我们旨在评估这些患者对全身性唑类抗真菌药的反应。
方法
我们从我们的机构的电子病历中查询了因过敏斑贴试验而转介、最终被诊断为头部和颈部皮炎并在两年内接受口服唑类抗真菌药物治疗的患者。
结果
24 名患者符合纳入标准并进行了分析。大多数患者指出，他们的特征性皮疹始于青少年、成年早期或成年期。所有患者均有头部和颈部的一定程度受累，17 例患者对治疗有反应。服用唑类抗真菌药物的平均时间为 8 个月，平均总体随访时间为 10 个月。
局限性
这是一项回顾性描述性研究，来自单一机构，涉及的患者数量有限，且未使用经过验证的评分系统。
结论
伊曲康唑和其他唑类抗真菌药对超过三分之二的头部和颈部特应性皮炎为主的成年患者是一种有效的治疗方法。
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