Martinez M, Simon V M, Castaño D, Brain P F
Area de Psicobiología, Facultad de Psicología, Universitat de València, Apartado 22109, 46071 Valencia, Spain.
Biomedical and Physiological Research Group, Biomedical Sciences, University College of Swansea, Singleton Park, Swansea SA2 8PP. U.K.
Behav Processes. 1989 Dec;20(1-3):125-37. doi: 10.1016/0376-6357(89)90018-1.
The potential influence of the type of opponent used in intermale aggression encounters to assess the actions of drugs was examined. Two experiments were carried out, one with the antiandrogen Cyproterone Acetate and the other with the antioestrogen CI-680 (both administered every three days over 25 days). In both experiments the antihormone-treated subjects encountered different opponents, namely: a) an antihormone-treated male, b) a non aggressive anosmic male or c) a vehicle-treated male. Vehicle-treated subjects also confronted a vehicle-treated or an anosmic opponent. The behaviour displayed by antihormone-treated subjects varied according to the characteristics of the partner, suggesting that the effects of drugs might be interpreted differently depending on the type of animal employed as an adversary. In fact, some of the apparently contradictory results reported in the literature seem to be consequences of the utilisation of different kinds of opponents. It is concluded that the choice of the opponent is of paramount importance in the study of drug actions on intermale aggression tests and that using more than one type of opponent can provide more complete information about the actions of particular drugs.
研究了在雄性间攻击行为实验中用于评估药物作用的对手类型的潜在影响。进行了两项实验，一项使用抗雄激素醋酸环丙孕酮，另一项使用抗雌激素CI-680（均在25天内每三天给药一次）。在两项实验中，接受抗激素治疗的受试者面对不同的对手，即：a）接受抗激素治疗的雄性，b）无攻击性的嗅觉缺失雄性或c）接受赋形剂治疗的雄性。接受赋形剂治疗的受试者也面对接受赋形剂治疗的或嗅觉缺失的对手。接受抗激素治疗的受试者表现出的行为根据对手的特征而有所不同，这表明药物的作用可能会根据用作对手的动物类型而有不同的解释。事实上，文献中报道的一些明显相互矛盾的结果似乎是使用不同类型对手的结果。得出的结论是，在研究药物对雄性间攻击行为测试的作用时，对手的选择至关重要，使用不止一种类型的对手可以提供有关特定药物作用的更完整信息。
