The Scripps Research Institute, La Jolla, CA 92037, USA.
Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Science. 2014 Jun 13;344(6189):1237. doi: 10.1126/science.1254082.
Lucifora et al. (Research Articles, 14 March 2014, p. 1221) report that the hepatitis B virus (HBV) transcriptional template, a long-lived covalently closed circular DNA (cccDNA) molecule, is degraded noncytolytically by agents that up-regulate APOBEC3A and 3B. If these results can be independently confirmed, they would represent a critical first step toward development of a cure for the 400 million patients who are chronically infected by HBV.
吕西弗拉等人（研究文章，2014 年 3 月 14 日，第 1221 页）报告称，乙型肝炎病毒（HBV）转录模板是一种长寿的共价闭合环状 DNA（cccDNA）分子，可被上调 APOBEC3A 和 3B 的药物非细胞溶酶体降解。如果这些结果能够得到独立证实，它们将成为开发治愈 4 亿名慢性 HBV 感染者的治疗方法的关键第一步。
