Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland. Brain Research Institute, University of Zurich, Zurich, Switzerland.
Brain Research Institute, University of Zurich, Zurich, Switzerland.
Science. 2014 Jun 13;344(6189):1250-5. doi: 10.1126/science.1253050.
The brain exhibits limited capacity for spontaneous restoration of lost motor functions after stroke. Rehabilitation is the prevailing clinical approach to augment functional recovery, but the scientific basis is poorly understood. Here, we show nearly full recovery of skilled forelimb functions in rats with large strokes when a growth-promoting immunotherapy against a neurite growth-inhibitory protein was applied to boost the sprouting of new fibers, before stabilizing the newly formed circuits by intensive training. In contrast, early high-intensity training during the growth phase destroyed the effect and led to aberrant fiber patterns. Pharmacogenetic experiments identified a subset of corticospinal fibers originating in the intact half of the forebrain, side-switching in the spinal cord to newly innervate the impaired limb and restore skilled motor function.
大脑在中风后恢复丧失的运动功能的能力有限。康复是增强功能恢复的主要临床方法，但科学基础理解得很差。在这里，我们在大鼠中展示了在大型中风后熟练的前肢功能几乎完全恢复，当应用一种促进生长的免疫疗法来抑制神经突生长抑制蛋白时，促进新纤维的发芽，然后通过强化训练来稳定新形成的回路。相比之下，在生长阶段早期进行高强度训练会破坏这种效果，并导致纤维模式异常。药物遗传学实验确定了起源于大脑前半部分的完整部分的皮质脊髓纤维的一个子集，在脊髓中侧移到新支配受损肢体并恢复熟练的运动功能。
