碳酸酐酶 9（CAIX）不能区分良性和恶性间皮。
Carbonic anhydrase IX (CAIX) does not differentiate between benign and malignant mesothelium.
机构信息
From the Department of Pathology, University of Chicago, Chicago, IL, and.
Department of Pathology, University of Washington, Seattle.
出版信息
Am J Clin Pathol. 2014 Jul;142(1):82-7. doi: 10.1309/AJCP8BJ8CJXUEHZD.
OBJECTIVES
To examine carbonic anhydrase IX (CAIX), a marker of renal cell carcinoma that recently has been described in malignant effusions.
METHODS
Pleural and peritoneal fluids with the following diagnoses-reactive (n = 23), carcinoma (n = 17), and "suspicious for mesothelioma" (n = 4)-were immunostained for CAIX, calretinin, Ber-EP4, and MOC31. A tissue microarray of epithelioid (n = 27) and sarcomatoid (n = 8) mesotheliomas and three cases of benign mesothelium were also immunostained for CAIX.
RESULTS
Mesothelial cells in both reactive (18/23) and malignant effusions (18/21) were positive for CAIX (P > .05). In carcinomatous effusions, CAIX expression was restricted to the mesothelial cells. Agreement between CAIX and calretinin expression was present in 89% of cases. In tissues, CAIX was positive in 100% of benign and 91% of malignant mesothelium.
CONCLUSIONS
CAIX can be a useful ancillary marker for identifying mesothelial cells. There is no difference in CAIX expression between benign and malignant mesothelium. Caution should be exercised while evaluating for metastasis from renal cell carcinoma.
目的
检测碳酸酐酶 IX（CAIX），一种最近在恶性渗出液中被描述的肾细胞癌标志物。
方法
对以下诊断的胸腔积液和腹腔积液进行免疫染色：反应性（n=23）、癌性（n=17）和“疑似间皮瘤”（n=4）。还对上皮样（n=27）和肉瘤样（n=8）间皮瘤的组织微阵列以及 3 例良性间皮进行了 CAIX、钙视网膜蛋白、Ber-EP4 和 MOC31 的免疫染色。
结果
反应性（23/23）和恶性渗出液（21/21）中的间皮细胞均为 CAIX 阳性（P＞.05）。在癌性渗出液中，CAIX 表达仅限于间皮细胞。CAIX 和钙视网膜蛋白表达之间存在 89%的一致性。在组织中，100%的良性和 91%的恶性间皮均为 CAIX 阳性。
结论
CAIX 可作为鉴定间皮细胞的有用辅助标志物。良性和恶性间皮之间的 CAIX 表达没有差异。在评估肾细胞癌转移时应谨慎。
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