Maradni Azam, Khoshnevisan Alireza, Mousavi Seyed Hamzeh, Emamirazavi Seyed Hasan, Noruzijavidan Abbas
General practitioner, Brain and spinal injury repair research center (BASIR), Tehran University of Medical Sciences, Tehran, Iran.
Assistant Professor, Department of Neurosurgery, Brain and spinal injury repair research center, Tehran University of medical sciences, Tehran, Iran.
Med J Islam Repub Iran. 2013 Nov;27(4):249-54.
Cerebrovascular disease is one of the leading causes of death in the world, and about one-fourth of cerebrovasculardeaths are due to ruptured cerebral aneurysms (CA). Hence it is important to find a way to reduce aneurysmformation and its subsequent morbidity and mortality. Proteolytic activity capable of lysing gelatin hasbeen shown to be increased in aneurysm tissue and expression of plasmin, membrane-type matrix metalloproteinase-1(MT1-MMP), and matrix metalloproteinase-2 (MMP-2) in aneurysmal wall is more than what we observein normal cerebral arteries. MMP inhibitors such as doxycycline and statins may prohibit aneurysm formationand growth. MMPs are important in tissue remodeling associated with various physiological and pathologicalprocesses such as morphogenesis, angiogenesis, apoptosis and tissue repair. In this article we review therole of MMPs and MMP inhibitors in formation of aneurysm.
脑血管疾病是全球主要死因之一，约四分之一的脑血管死亡是由脑动脉瘤（CA）破裂所致。因此，找到一种减少动脉瘤形成及其后续发病率和死亡率的方法很重要。已证明能够溶解明胶的蛋白水解活性在动脉瘤组织中增加，并且动脉瘤壁中纤溶酶、膜型基质金属蛋白酶-1（MT1-MMP）和基质金属蛋白酶-2（MMP-2）的表达高于我们在正常脑动脉中观察到的水平。强力霉素和他汀类等MMP抑制剂可能会抑制动脉瘤的形成和生长。MMP在与各种生理和病理过程（如形态发生、血管生成、细胞凋亡和组织修复）相关的组织重塑中起重要作用。在本文中，我们综述了MMP和MMP抑制剂在动脉瘤形成中的作用。
