Pandey Awanish K, Gupta Prem P, Lal Vijay K
J Complement Integr Med. 2014 Sep;11(3):179-83. doi: 10.1515/jcim-2012-0057.
Rhizophora mucronata, plant of Mangroove family, found on the coastal region of India and used in treatment of various diseases. Different parts of plants are used in treatment of diabetes as folkloric medicine. The present study was designed to evaluate the hypoglycemic effect of hydro-alcoholic extract of R. mucronata. Streptozotocin (STZ)-induced diabetic rats were treated with RME (100 mg/kg and 200 mg/kg) and glibenclamide (0.5 mg/kg). Blood glucose levels were evaluated for the acute and sub-acute studies and body weight of rats were also monitored. All the treatments showed the highly significant (p<0.01) hypoglycemic effect in both the acute and the sub-acute studies. RME and glibenclamide treated rats were maintained the body weight during the study period while as the body weight of diabetic rats had gone down. The result of this study scientifically proved the hypoglycemic folkloric use of leaves of R. mucronata in treatment of diabetes.
红树科植物红海榄，生长于印度沿海地区，可用于治疗多种疾病。作为民间药物，该植物的不同部位用于治疗糖尿病。本研究旨在评估红海榄水醇提取物的降血糖作用。用链脲佐菌素（STZ）诱导糖尿病大鼠，分别用红海榄提取物（100毫克/千克和200毫克/千克）和格列本脲（0.5毫克/千克）进行治疗。在急性和亚急性研究中评估血糖水平，并监测大鼠体重。在急性和亚急性研究中，所有治疗均显示出高度显著（p<0.01）的降血糖作用。在研究期间，用红海榄提取物和格列本脲治疗的大鼠体重得以维持，而糖尿病大鼠的体重则下降。本研究结果科学地证明了红海榄叶在治疗糖尿病方面的民间降血糖用途。
