Jaiswal Dolly, Kumar Rai Prashant, Kumar Amit, Mehta Shikha, Watal Geeta
Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Lab, Department of Chemistry, University of Allahabad, Allahabad, U.P. 211002, India.
J Ethnopharmacol. 2009 Jun 25;123(3):392-6. doi: 10.1016/j.jep.2009.03.036. Epub 2009 Apr 5.
In Indian traditional system of medicine, Moringa oleifera Lam. Syn. Moringa pterygosperma Gaerth (Moringaceae) is commonly used as healing herb to treat diabetes.
The purpose of the present study was to assess the effect of M. oleifera leaves aqueous extract therapy on glycemic control, haemoglobin, total protein, urine sugar, urine protein and body weight.
Variable doses of 100, 200 and 300 mg kg(-1) of aqueous extract were administered orally by gavage for evaluating their hypoglycemic and antidiabetic effects on fasting blood glucose (FBG), oral glucose tolerance test (OGTT) and post prandial glucose (PPG) of normal and streptozotocin (STZ) induced sub, mild and severely diabetic rats.
The dose of 200 mg kg(-1) decreases blood glucose level (BGL) of normal animals by 26.7 and 29.9% during FBG and OGTT studies respectively. In sub and mild diabetic animals the same dose produced a maximum fall of 31.1 and 32.8% respectively, during OGTT. In case of severely diabetic animals FBG and PPG levels were reduced by 69.2 and 51.2% whereas, total protein, body weight and haemoglobin were increased by 11.3, 10.5 and 10.9% respectively after 21 days of treatment. Significant reduction was found in urine sugar and urine protein levels from +4 and +2 to nil and trace, respectively.
The study validates scientifically the widely claimed use of M. oleifera as an ethnomedicine to treat diabetes mellitus.
在印度传统医学体系中，辣木（Moringa oleifera Lam. 同义词：Moringa pterygosperma Gaerth，辣木科）通常被用作治疗糖尿病的草药。
本研究的目的是评估辣木叶水提取物疗法对血糖控制、血红蛋白、总蛋白、尿糖、尿蛋白和体重的影响。
通过灌胃法口服给予100、200和300 mg kg(-1) 的不同剂量水提取物，以评估其对正常大鼠以及链脲佐菌素（STZ）诱导的亚临床、轻度和重度糖尿病大鼠的空腹血糖（FBG）、口服葡萄糖耐量试验（OGTT）和餐后血糖（PPG）的降血糖和抗糖尿病作用。
在FBG和OGTT研究中，200 mg kg(-1) 的剂量分别使正常动物的血糖水平（BGL）降低了26.7%和29.9%。在亚临床和轻度糖尿病动物中，相同剂量在OGTT期间分别产生了最大降幅31.1%和32.8%。对于重度糖尿病动物，治疗21天后，FBG和PPG水平分别降低了69.2%和51.2%，而总蛋白、体重和血红蛋白分别增加了11.3%、10.5%和10.9%。尿糖和尿蛋白水平从+4和+2分别显著降低至零和微量。
该研究科学验证了辣木作为治疗糖尿病的民族药物的广泛应用。
