维生素D缺乏与成人哮喘急性发作

Vitamin D deficiency and adult asthma exacerbations.

作者信息

Salas Natalie Mariam, Luo Li, Harkins Michelle S

机构信息

Department of Internal Medicine, University of New Mexico Health Sciences Center , Albuquerque, NM , USA.

出版信息

J Asthma. 2014 Nov;51(9):950-5. doi: 10.3109/02770903.2014.930883. Epub 2014 Jul 2.

DOI:10.3109/02770903.2014.930883

PMID:24926743

Abstract

OBJECTIVES

There is growing evidence indicating a connection between vitamin D deficiency and the severity of asthma exacerbations. This study seeks to assess the relationship between vitamin D deficiency and the number and severity of asthma exacerbation in adults.

METHODS

A retrospective analysis was conducted in 92 patients being treated for asthma at the University of New Mexico Adult Asthma Clinic. Serum 25-hydroxyvitamin D3 levels were analyzed in adults with mild to severe persistent asthma. Using multi-variant modeling, the relationship was examined between serum vitamin D levels and the odds of asthma exacerbations ranging in severity from moderate to severe over the span of five years.

RESULTS

This study demonstrates that vitamin D sufficiency was significantly associated with a decreased total number of asthma exacerbations (incidence rate ratio [IRR]: 0.61, 95% confidence interval [CI]: 0.44-0.84, p = 0.002), decreased total severe asthma exacerbations (IRR: 0.41, 95% CI: 0.24-0.72, p = 0.002) and decreased emergency room visits (IRR: 0.42, 95% CI: 0.20-0.88, p = 0.023).

CONCLUSION

Vitamin D deficiency may be linked to the risk of severe asthma exacerbations in adults.

摘要

目的

越来越多的证据表明维生素D缺乏与哮喘急性加重的严重程度之间存在关联。本研究旨在评估成人维生素D缺乏与哮喘急性加重的次数及严重程度之间的关系。

方法

对在新墨西哥大学成人哮喘诊所接受哮喘治疗的92例患者进行回顾性分析。分析了轻度至重度持续性哮喘成人的血清25-羟维生素D3水平。使用多变量模型，研究了血清维生素D水平与五年内中度至重度哮喘急性加重几率之间的关系。

结果

本研究表明，维生素D充足与哮喘急性加重总数减少显著相关（发病率比[IRR]：0.61，95%置信区间[CI]：0.44-0.84，p = 0.002），严重哮喘急性加重总数减少（IRR：0.41，95%CI：0.24-0.72，p = 0.002），以及急诊就诊次数减少（IRR：0.42，95%CI：0.20-0.88，p = 0.023）。