Wee Jee Hye, Min Chanyang, Park Min Woo, Byun Soo Hwan, Lee Hyo-Jeong, Park Bumjung, Choi Hyo Geun
Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, 22, Gwanpyeong-ro 170 beon-gil, Dongan-gu, Anyang, 14068 Republic of Korea.
Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Korea.
Allergy Asthma Clin Immunol. 2020 Sep 25;16:84. doi: 10.1186/s13223-020-00482-6. eCollection 2020.
A few studies have reported the association between asthma and osteoporosis. We aimed to analyze the association of asthma and its subgroups with osteoporosis in the Korean adult population.
We used the health examinee (HEXA) data from the Korean Genome and Epidemiology Study (KoGES) obtained between 2004 and 2016. We included 162,579 participants (n = 3,160 with asthma; n = 159,419 controls) who reported their previous histories of asthma and osteoporosis. The participants were categorized into 3 groups based on asthma management: participants who did not need further treatment due to controlled symptoms (well controlled); participants with ongoing treatment (being treated); participants who were not treated even though they had symptoms (not being treated). Multiple logistic regression analyses were used to calculate the adjusted odds ratios (aORs) with 95% confidence intervals (CIs) for osteoporosis. Subgroup analyses for age and sex were conducted.
The prevalence of osteoporosis was higher in patients with asthma (13.6%) than in controls (6.8%). In the full-adjusted model, the aORs for osteoporosis were 1.74 (95% CI 1.55-1.94, P < 0.001) in patients with asthma compared to controls. There were consistent findings across the age and sex subgroups. The aORs for osteoporosis were 1.43 (95% CI 1.10-1.86, P = 0.008) in the well-controlled asthma group; 1.55 (95% CI 1.28-1.89, P < 0.001) in the being treated asthma group; and 1.96 (95% CI 1.66-2.31, P < 0.001) in the not being treated asthma group compared to the control group.
Asthma was associated with osteoporosis in the Korean adult population. Patients with asthma not being treated showed the highest ORs for osteoporosis.
一些研究报告了哮喘与骨质疏松症之间的关联。我们旨在分析韩国成年人群中哮喘及其亚组与骨质疏松症的关联。
我们使用了2004年至2016年间从韩国基因组与流行病学研究（KoGES）中获得的健康体检者（HEXA）数据。我们纳入了162,579名参与者（n = 3,160名哮喘患者；n = 159,419名对照），他们报告了自己既往的哮喘和骨质疏松症病史。参与者根据哮喘管理情况分为3组：因症状得到控制而无需进一步治疗的参与者（控制良好）；正在接受治疗的参与者（正在治疗）；即使有症状也未接受治疗的参与者（未治疗）。采用多元逻辑回归分析计算骨质疏松症的调整优势比（aOR）及其95%置信区间（CI）。进行了年龄和性别的亚组分析。
哮喘患者的骨质疏松症患病率（13.6%）高于对照组（6.8%）。在完全调整模型中，与对照组相比，哮喘患者骨质疏松症的aOR为1.74（95%CI 1.55 - 1.94，P < 0.001）。在年龄和性别亚组中发现了一致的结果。与对照组相比，哮喘控制良好组骨质疏松症的aOR为1.43（95%CI 1.10 - 1.86，P = 0.008）；正在治疗的哮喘组为1.55（95%CI 1.28 - 1.89，P < 0.001）；未治疗的哮喘组为1.96（95%CI 1.66 - 2.31，P < 0.001）。
在韩国成年人群中，哮喘与骨质疏松症有关。未接受治疗的哮喘患者骨质疏松症的OR最高。
