Department of Psychiatry, St Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada.
Int J Psychiatry Clin Pract. 1997;1(1):3-13. doi: 10.3109/13651509709069200.
The serotonergic system has been linked to the etiology of several, albeit disparate, psychiatric disorders. The accumulation of many lines of evidence support the view that there are gender differences in the serotonergic system in humans. It is further proposed that a gender differentiated serotonergic system acts as the nidus for the development of gender-specific psychiatric disorders. Depression, anxiety and eating disorders are largely seen in females, whereas alcoholism, aggressivity and suicide predominate in males. Evidence from both animal and human studies suggesting that the serotonergic system mediates between social-environmental experience and biological states is presented and reviewed. A reconceptualization of the serotonergic system as a gender-specific psychobiological interface is proposed. (Int J Psych Clin Prac 1997; 1: 3-13).
血清素能系统与几种不同的精神疾病的病因有关。越来越多的证据支持这样一种观点，即人类的血清素能系统存在性别差异。进一步提出的是，性别差异的血清素能系统作为发展特定性别精神疾病的核心。抑郁症、焦虑症和饮食失调症在女性中很常见，而酗酒、攻击性和自杀在男性中更为普遍。本文提出并回顾了来自动物和人类研究的证据，表明血清素能系统在社会环境经验和生物状态之间起中介作用。本文提出将血清素能系统重新概念化为一种特定性别的心理生物学界面。（《国际心理临床实践杂志》1997 年；1:3-13）。
