Liu Meng-Jia, Zou Li-Ping
Children's Medical Center, General Hospital of People's Liberation Army, Beijing 100853, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2014 Jun;16(6):571-4.
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most prevalent type of encephalitis. Investigating the pathogenesis of anti-NMDAR encephalitis will enhance our understanding of this disease and play a central part in providing reasonable treatment for the patients. The pathogenesis is elucidated as follows: (1) the findings of the relationship between anti-NMDAR encephalitis and tumors; (2) further research on the relationship between anti-NMDAR encephalitis and tumors; (3) NMDAR epitopes and the autoimmunity of patients; (4) the interaction between antibody and NMDAR; (5) the pathogenesis of anti-NMDAR encephalitis without tumors. This review gives a brief introduction to the methodology and way of finding out the valuable clinical problems and making a clear and explicit explanation of them by exhibiting the process of discovering the disease, disclosing its relationship with tumors, and investigating its pathological and molecular mechanism. Current studies have demonstrated that anti-NMDAR encephalitis is an autoimmune disease of the nervous system that is closely associated with tumors, particularly ovarian teratoma.
抗N-甲基-D-天冬氨酸受体（NMDAR）脑炎是最常见的脑炎类型。研究抗NMDAR脑炎的发病机制将增进我们对该疾病的了解，并在为患者提供合理治疗方面发挥核心作用。其发病机制阐述如下：（1）抗NMDAR脑炎与肿瘤之间关系的研究结果；（2）对抗NMDAR脑炎与肿瘤之间关系的进一步研究；（3）NMDAR表位与患者自身免疫性；（4）抗体与NMDAR之间的相互作用；（5）无肿瘤的抗NMDAR脑炎的发病机制。本综述通过展示发现该疾病的过程、揭示其与肿瘤的关系以及研究其病理和分子机制，简要介绍了找出有价值的临床问题并对其进行清晰明确解释的方法和途径。目前的研究表明，抗NMDAR脑炎是一种与肿瘤尤其是卵巢畸胎瘤密切相关的神经系统自身免疫性疾病。
