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[软骨的形态学与功能成像]

[Morphological and functional cartilage imaging].

作者信息

Rehnitz C, Weber M-A

机构信息

Diagnostische und Interventionelle Radiologie, Universitätsklinikum Heidelberg, INF 110, 69120, Heidelberg, Deutschland,

出版信息

Radiologe. 2014 Jun;54(6):599-615; quiz 616-7. doi: 10.1007/s00117-014-2663-1.

Abstract

Excellent morphological imaging of cartilage is now possible and allows the detection of subtle cartilage pathologies. Besides the standard 2D sequences, a multitude of 3D sequences are available for high-resolution cartilage imaging. The first part therefore deals with modern possibilities of morphological imaging. The second part deals with functional cartilage imaging with which it is possible to detect changes in cartilage composition and thus early osteoarthritis as well as to monitor biochemical changes after therapeutic interventions. Validated techniques such as delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T2 mapping as well the latest techniques, such as the glycosaminoglycan chemical exchange-dependent saturation transfer (gagCEST) technique will be discussed.

摘要

现在可以对软骨进行出色的形态学成像,并能检测出细微的软骨病变。除了标准的二维序列外,还有多种三维序列可用于高分辨率软骨成像。因此,第一部分论述形态学成像的现代方法。第二部分论述软骨功能成像,通过它可以检测软骨成分的变化,从而早期发现骨关节炎,并监测治疗干预后的生化变化。将讨论经过验证的技术,如延迟钆增强磁共振软骨成像(dGEMRIC)和T2 mapping,以及最新技术,如糖胺聚糖化学交换依赖饱和转移(gagCEST)技术。

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