Choi Seo Young, Park Seong-Ho, Kim Hyo-Jung, Kim Ji-Soo
Department of Neurology, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.
Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seoul, Republic of Korea.
J Neurol Sci. 2014 Aug 15;343(1-2):187-91. doi: 10.1016/j.jns.2014.05.030. Epub 2014 Jun 2.
A 52-year-old man with vertigo and imbalance for two weeks showed spontaneous downbeat (DBN), horizontal gaze-evoked, and positional apogeotropic nystagmus along with severe limb and truncal ataxia. Gadolinium-enhanced brain MRI was normal, but whole body and brain 2-deoxy-2-[F18]fluoro-d-glucose-positron emission tomography revealed hypermetabolism in the right lower lobe of the lung and the cerebellum, especially in the nodulus. The lesion in the lung was confirmed as mixed cell carcinoma. Paraneoplastic DBN may be associated with cerebellar hypermetabolism, especially in the nodulus.
一名52岁男性，有两周的眩晕和失衡症状，表现为自发性下跳性（DBN）、水平凝视诱发性和位置性背地性眼球震颤，伴有严重的肢体和躯干共济失调。钆增强脑MRI正常，但全身和脑部2-脱氧-2-[F18]氟-D-葡萄糖正电子发射断层扫描显示右肺下叶和小脑，尤其是小结节处代谢亢进。肺部病变经证实为混合细胞癌。副肿瘤性DBN可能与小脑代谢亢进有关，尤其是在小结节处。
