Matsumoto Hideyuki, Sengoku Renpei, Saito Yuko, Kakuta Yukio, Murayama Shigeo, Imafuku Ichiro
Department of Neurology, Japanese Red Cross Medical Center, Japan; Department of Neurology, Yokohama Rosai Hospital, Japan.
Department of Neurology and Neuropathology, Tokyo Metropolitan Geriatric Hospital, Japan.
J Neurol Sci. 2014 Aug 15;343(1-2):149-52. doi: 10.1016/j.jns.2014.05.060. Epub 2014 Jun 2.
The aim of this paper is to reveal the causes of death and to verify sudden death of Parkinson's disease (PD) in an autopsy study. We reviewed the clinical data and the causes of death in 16 PD patients who had postmortem examinations. Prior to autopsy, nine patients died of known causes: five patients died of aspiration pneumonia, two of myocardial infarction, one of asphyxia, and one of dilated cardiomyopathy. Autopsy confirmed that the putative causes of death were compatible with the pathological ones. The remaining seven patients died suddenly of unknown causes. Autopsy revealed that the causes of death were asphyxia in two patients and perforation of a duodenal ulcer in one patient. Autopsy did not determine the causes of unknown death in the remaining four patients. Consequently, autopsy revealed that eight patients died of swallowing problems such as aspiration pneumonia and asphyxia, four of sudden death, three of cardiac problems, and one of a gastrointestinal problem. Although there was a bias that all patients had a postmortem examination, our study revealed that several PD patients died of sudden death without any satisfactory causes of death determined even by autopsy. Therefore, we propose that a non-negligible number of PD patients die of sudden death.
本文旨在通过一项尸检研究揭示帕金森病（PD）的死亡原因并核实猝死情况。我们回顾了16例接受尸检的PD患者的临床资料及死亡原因。尸检前，9例患者死于已知原因：5例死于吸入性肺炎，2例死于心肌梗死，1例死于窒息，1例死于扩张型心肌病。尸检证实推定的死亡原因与病理结果相符。其余7例患者死因不明且突然死亡。尸检显示，2例患者死于窒息，1例患者死于十二指肠溃疡穿孔。尸检未确定其余4例患者死因不明的原因。因此，尸检显示8例患者死于吞咽问题，如吸入性肺炎和窒息，4例死于猝死，3例死于心脏问题，1例死于胃肠道问题。尽管所有患者均接受尸检存在一定偏差，但我们的研究表明，即使通过尸检，仍有若干PD患者死于猝死且死因不明。因此，我们认为有相当数量的PD患者死于猝死。
