Ponte J, Sadler C L
Department of Anaesthesia, Kings's College School of Medicine and Dentistry, London.
Br J Anaesth. 1989 Jan;62(1):41-5. doi: 10.1093/bja/62.1.41.
The response of the carotid body chemoreceptors to intracarotid administration of thiopentone, etomidate and propofol was tested in the rabbit and cat. Thiopentone 3-6 mg min-1 and etomidate 300-600 micrograms min-1 were mildly excitatory, shifting the oxygen and carbon dioxide response curves upwards. Propofol 1.5-3.0 mg min-1 was a potent chemodepressant and abolished discharge at PaO2 values greater than 8 kPa. Prolonged infusion of propofol at higher rates (6 mg min-1) abolished the response to hypoxia completely. The significance of these results is discussed in relation to the known ventilatory effects of the three anaesthetics.
在兔和猫身上测试了颈动脉体化学感受器对颈内注射硫喷妥钠、依托咪酯和丙泊酚的反应。硫喷妥钠3 - 6毫克/分钟和依托咪酯300 - 600微克/分钟有轻度兴奋作用，使氧和二氧化碳反应曲线向上移动。丙泊酚1.5 - 3.0毫克/分钟是一种强效化学抑制剂，在动脉血氧分压大于8千帕时可消除放电。以更高速率（6毫克/分钟）长时间输注丙泊酚可完全消除对低氧的反应。结合这三种麻醉药已知的通气效应讨论了这些结果的意义。
