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硫喷妥钠、依托咪酯和丙泊酚对气管插管血流动力学反应的影响。

Effects of thiopentone, etomidate and propofol on the haemodynamic response to tracheal intubation.

作者信息

Harris C E, Murray A M, Anderson J M, Grounds R M, Morgan M

机构信息

Department of Anaesthetics, Royal Postgraduate Medical School, London.

出版信息

Anaesthesia. 1988 Mar;43 Suppl:32-6. doi: 10.1111/j.1365-2044.1988.tb09065.x.

Abstract

The haemodynamic response to tracheal intubation was compared in 303 patients in whom anaesthesia was induced with either thiopentone 4 mg/kg, etomidate 0.3 mg/kg or propofol 2.5 mg/kg, with and without fentanyl 2 micrograms/kg. There was after propofol alone a significant decrease in arterial blood pressure, which did not increase above control values after intubation. Significant increases in arterial pressure followed intubation in patients induced with thiopentone or etomidate alone. Increases in heart rate occurred with all agents after laryngoscopy. The use of fentanyl resulted in arterial pressures lower than those after the induction agent alone, and in an attenuation, but not abolition of the responses to laryngoscopy and intubation.

摘要

对303例患者进行了比较,这些患者分别使用4mg/kg硫喷妥钠、0.3mg/kg依托咪酯或2.5mg/kg丙泊酚诱导麻醉,且部分患者加用或未加用2μg/kg芬太尼,观察气管插管时的血流动力学反应。单独使用丙泊酚后动脉血压显著下降,插管后未升至对照值以上。单独使用硫喷妥钠或依托咪酯诱导的患者插管后动脉压显著升高。喉镜检查后,所有药物均使心率增加。使用芬太尼导致动脉压低于单独使用诱导药物后的水平,并使对喉镜检查和插管的反应减弱,但未消除。

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