Vajda F J E, O'Brien T J, Graham J, Lander C M, Eadie M J
Department of Medicine and Neurosciences, Royal Melbourne Hospital and University of Melbourne, Grattan Street, Parkville, VIC 3050, Australia.
Department of Medicine and Neurosciences, Royal Melbourne Hospital and University of Melbourne, Grattan Street, Parkville, VIC 3050, Australia.
J Clin Neurosci. 2014 Sep;21(9):1478-82. doi: 10.1016/j.jocn.2013.11.049. Epub 2014 Jun 10.
The demographic characteristics, details of pregnancies, epilepsies, and treatment of 855 pregnant women with epilepsy enrolled in the Australian Antiepileptic Drugs in Pregnancy Register during 1999-2005 were compared with the corresponding data for the 801 women enrolled from 2006-2012. We estimate that the Register captures approximately 1 in 12 of all pregnancies in Australian women with epilepsy. A number of statistically significant changes were found, with nearly all explained by factors such as re-enrolment of women who had enrolled earlier pregnancies, changes in general population behaviour, altered attitudes to prescribing valproate and using it in lower doses, and the advent of newer antiepileptic drugs which have displaced the use of older agents. It appears that the Register has continued to capture a reasonably representative sample of pregnant Australian women with epilepsy as time has passed.
对1999年至2005年期间纳入澳大利亚孕期抗癫痫药物登记册的855名癫痫孕妇的人口统计学特征、妊娠细节、癫痫情况及治疗情况，与2006年至2012年纳入的801名女性的相应数据进行了比较。我们估计，该登记册涵盖了澳大利亚癫痫女性所有妊娠中的约十二分之一。发现了一些具有统计学意义的变化，几乎所有变化都可由以下因素解释，如早期妊娠已登记女性的重新登记、一般人群行为的变化、对丙戊酸盐处方态度的改变及使用剂量降低、以及新型抗癫痫药物的出现取代了旧药物的使用。随着时间的推移，该登记册似乎继续获取了澳大利亚癫痫孕妇的一个具有合理代表性的样本。
