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激发联系:促进研究与人类健康政策之间更好的联系——以多壁碳纳米管为例。

Sparking connections: toward better linkages between research and human health policy-an example with multiwalled carbon nanotubes.

作者信息

Powers Christina M, Gift Jeff, Lehmann Geniece M

机构信息

National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711.

National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711

出版信息

Toxicol Sci. 2014 Sep;141(1):6-17. doi: 10.1093/toxsci/kfu117. Epub 2014 Jun 13.

Abstract

Risk assessment and subsequent risk management of environmental contaminants can benefit from early collaboration among researchers, risk assessors, and risk managers. The benefits of collaboration in research planning are particularly evident in light of (1) increasing calls to expand upon the risk assessment paradigm to include a greater focus on problem formulation and consideration of potential tradeoffs between risk management options, and (2) decreasing research budgets. Strategically connecting research planning to future decision making may be most critical in areas of emerging science for which data are often insufficient to clearly direct targeted research to support future risk assessment and management efforts. This article illustrates an application of the comprehensive environmental assessment approach to inform research planning for future risk assessment and management of one emerging material, multiwalled carbon nanotubes (MWCNTs). High-priority research areas identified for MWCNTs in flame-retardant coatings applied to upholstery textiles included the following: release across the product life cycle; environmental transport, transformation and fate in air, wastewater and sediment; exposure in human occupational and consumer groups; kinetics in the human body; impacts on human health and aquatic populations; and impacts on economic, social, and environmental resources. This article focuses on specific research questions related to human health and how these may connect to future risk assessments and risk management efforts. Such connections will support more effective collaborations across the scientific community and may inform the prioritization of research funding opportunities for emerging materials like MWCNTs.

摘要

环境污染物的风险评估及后续风险管理可受益于研究人员、风险评估人员和风险管理人员之间的早期合作。鉴于以下两点,合作在研究规划中的益处尤为明显:(1)越来越多的呼声要求扩展风险评估范式,以更注重问题的形成以及对风险管理选项之间潜在权衡的考量;(2)研究预算不断减少。在新兴科学领域,将研究规划与未来决策进行战略性连接可能最为关键,因为在这些领域,数据往往不足以明确指导有针对性的研究以支持未来的风险评估和管理工作。本文阐述了综合环境评估方法在为一种新兴材料——多壁碳纳米管(MWCNTs)的未来风险评估和管理提供研究规划信息方面的应用。在应用于室内装饰纺织品的阻燃涂层中,针对MWCNTs确定的高优先级研究领域包括:产品生命周期内的释放;在空气、废水和沉积物中的环境迁移、转化和归宿;人类职业和消费群体中的暴露;在人体内的动力学;对人类健康和水生生物种群的影响;以及对经济、社会和环境资源的影响。本文重点关注与人类健康相关的具体研究问题,以及这些问题如何与未来的风险评估和风险管理工作相联系。这种联系将支持科学界开展更有效的合作,并可能为确定MWCNTs等新兴材料的研究资金机会优先级提供参考。

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