PEDF 介导的对抗糖尿病视网膜病变和神经病变中活性氧损伤的保护机制。
Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy.
机构信息
College of Health and BiomedicineVictoria University, St Albans, Victoria 3021, AustraliaSchool of Biomedical SciencesBiosciences Research PrecinctSchool of PharmacyCurtin University, Bentley, Perth, Western Australia 6102, Australia.
College of Health and BiomedicineVictoria University, St Albans, Victoria 3021, AustraliaSchool of Biomedical SciencesBiosciences Research PrecinctSchool of PharmacyCurtin University, Bentley, Perth, Western Australia 6102, AustraliaCollege of Health and BiomedicineVictoria University, St Albans, Victoria 3021, AustraliaSchool of Biomedical SciencesBiosciences Research PrecinctSchool of PharmacyCurtin University, Bentley, Perth, Western Australia 6102, Australia.
出版信息
J Endocrinol. 2014 Sep;222(3):R129-39. doi: 10.1530/JOE-14-0065. Epub 2014 Jun 13.
Pigment epithelium-derived factor (PEDF) is a pluripotent glycoprotein belonging to the serpin family. PEDF can stimulate several physiological processes such as angiogenesis, cell proliferation, and survival. Oxidative stress plays an important role in the occurrence of diabetic retinopathy (DR), which is the major cause of blindness in young diabetic adults. PEDF plays a protective role in DR and there is accumulating evidence of the neuroprotective effect of PEDF. In this paper, we review the role of PEDF and the mechanisms involved in its antioxidative, anti-inflammatory, and neuroprotective properties.
色素上皮衍生因子（PEDF）是一种属于丝氨酸蛋白酶抑制剂家族的多功能糖蛋白。PEDF 可刺激多种生理过程，如血管生成、细胞增殖和存活。氧化应激在糖尿病性视网膜病变（DR）的发生中起着重要作用，DR 是年轻成年糖尿病患者失明的主要原因。PEDF 在 DR 中起保护作用，并且有越来越多的证据表明 PEDF 具有神经保护作用。本文综述了 PEDF 的作用及其在抗氧化、抗炎和神经保护特性中的相关机制。
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