糖尿病视网膜病变中的色素上皮衍生因子：氧化应激的保护作用
PEDF in diabetic retinopathy: a protective effect of oxidative stress.
作者信息
Zhu Xiao-feng, Zou Hai-dong
机构信息
Department of Ophthalmology, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.
出版信息
J Biomed Biotechnol. 2012;2012:580687. doi: 10.1155/2012/580687. Epub 2012 Apr 10.
Abstract
Diabetic retinopathy (DR) is a major cause of blindness in working age adults, and oxidative stress plays a vital role in the pathogenesis of DR. Pigment-epithelium-derived factor (PEDF), a multifunctional protein, has shown to inhibit the development of DR by accumulating evidence. This paper highlights the current understanding of probable mechanism about how PEDF blocks the deterioration of DR through its antioxidative properties and application prospects of PEDF as a novel therapeutic target in DR. Gene therapy of PEDF is becoming more and more acceptable and will widely be applied to the actual treatment in the near future.
摘要
糖尿病视网膜病变（DR）是工作年龄成年人失明的主要原因，氧化应激在DR的发病机制中起着至关重要的作用。色素上皮衍生因子（PEDF）是一种多功能蛋白质，越来越多的证据表明它能抑制DR的发展。本文重点阐述了目前对PEDF如何通过其抗氧化特性阻止DR恶化的可能机制的理解，以及PEDF作为DR新型治疗靶点的应用前景。PEDF的基因治疗越来越被人们接受，并将在不久的将来广泛应用于实际治疗中。
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本文引用的文献
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Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.高血糖激活蛋白激酶C-δ（PKC-δ）和蛋白酪氨酸磷酸酶-1（SHP-1）会导致血管细胞凋亡和糖尿病视网膜病变。
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