Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan; Japan Science and Technology Agency (JST), Explorative Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan; Japan Science and Technology Agency (JST), Explorative Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
Arch Biochem Biophys. 2014 Nov 1;561:118-23. doi: 10.1016/j.abb.2014.06.003. Epub 2014 Jun 12.
Bone and immune systems are tightly linked. In the past years, many molecules originally believed to belong to the immune system were found to function in bone cells. It is now evident that the two systems are coregulated by many shared cytokines and signaling molecules. Here we exemplify the complex interaction between bone metabolism and immune response focusing on the multifaceted role of receptor activator of NF-κB ligand (RANKL). RANKL is expressed by cells of both systems, is an essential regulator of bone degradation and exerts either pro or anti-inflammatory effects on the immune response. In the present review, we summarize the multiple functions of RANKL in bone and in the immune systems, aiming to provide an overview of the field of osteoimmunology.
骨骼和免疫系统紧密相连。在过去的几年中，许多原本被认为属于免疫系统的分子被发现存在于骨细胞中。现在很明显，这两个系统由许多共同的细胞因子和信号分子共同调节。在这里，我们以核因子-κB 受体激活配体（RANKL）的多方面作用为例，阐述了骨骼代谢与免疫反应之间的复杂相互作用。RANKL 由两个系统的细胞表达，是骨骼降解的必需调节剂，对免疫反应具有促炎或抗炎作用。在本综述中，我们总结了 RANKL 在骨骼和免疫系统中的多种功能，旨在提供骨免疫学领域的概述。
