Macau Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China.
MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Key Lab of Microanalytical Methods & Instrumentation, Department of Chemistry, Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China.
Molecules. 2022 Jun 8;27(12):3697. doi: 10.3390/molecules27123697.
Oliver () is a popular medicinal herb and health supplement in China, Japan, and Korea, and has a variety of pharmaceutical properties. The neuroendocrine-immune (NEI) network is crucial in maintaining homeostasis and physical or psychological functions at a holistic level, consistent with the regulatory theory of natural medicine. This review aims to systematically summarize the chemical compositions, biological roles, and pharmacological properties of to build a bridge between it and NEI-associated diseases and to provide a perspective for the development of its new clinical applications. After a review of the literature, we found that has effects on NEI-related diseases including cancer, neurodegenerative disease, hyperlipidemia, osteoporosis, insomnia, hypertension, diabetes mellitus, and obesity. However, clinical studies on were scarce. In addition, derivatives are diverse in China, and they are mainly used to enhance immunity, improve hepatic damage, strengthen bones, and lower blood pressure. Through network pharmacological analysis, we uncovered the possibility that is involved in functional interactions with cancer development, insulin resistance, NAFLD, and various inflammatory pathways associated with NEI diseases. Overall, this review suggests that has a wide range of applications for NEI-related diseases and provides a direction for its future research and development.
黄精是一种在中国、日本和韩国广受欢迎的药草和保健品，具有多种药物特性。神经内分泌免疫（NEI）网络对于在整体水平上维持内稳态和身体或心理功能至关重要，这与天然药物的调节理论一致。本综述旨在系统总结的化学成分、生物学作用和药理学特性，以期在 NEI 相关疾病之间架起桥梁，并为其新的临床应用提供研究视角。通过文献回顾，我们发现黄精对癌症、神经退行性疾病、高脂血症、骨质疏松症、失眠、高血压、糖尿病和肥胖等 NEI 相关疾病有一定的作用。然而，黄精的临床研究较为匮乏。此外，中国的黄精衍生物种类繁多，主要用于增强免疫力、改善肝损伤、增强骨骼和降低血压。通过网络药理学分析，我们揭示了黄精可能与癌症发展、胰岛素抵抗、非酒精性脂肪性肝病（NAFLD）以及与 NEI 疾病相关的各种炎症途径的功能相互作用有关。总的来说，本综述表明黄精对 NEI 相关疾病有广泛的应用前景，并为其未来的研究和开发提供了方向。
