Hossain Mohammad Sorowar, Iqbal Mohd S, Khan Mohiuddin Ahmed, Rabbani Mohammad Golam, Khatun Hazera, Munira Sirajam, Miah M Morshed Zaman, Kabir Amin Lutful, Islam Naima, Dipta Tashmim Farhana, Rahman Farzana, Mottalib Abdul, Afrose Salma, Ara Tasneem, Biswas Akhil Ranjan, Rahman Mizanur, Abedin Akm Mustafa, Rahman Mahbubur, Yunus A B M, Niessen Louis W, Sultana Tanvira Afroze
BRAC University, Mohakhali, Dhaka, Bangladesh.
BMC Cancer. 2014 Jun 14;14:438. doi: 10.1186/1471-2407-14-438.
The global burden from cancer is rising, especially as low-income countries like Bangladesh observe rapid aging. So far, there are no comprehensive descriptions reporting diagnosed cancer group that include hematological malignancies in Bangladesh.
This was a multi-center hospital-based retrospective descriptive study of over 5000 confirmed hematological cancer cases in between January 2008 to December 2012. Morphological typing was carried out using the "French American British" classification system.
A total of 5013 patients aged between 2 to 90 years had been diagnosed with malignant hematological disorders. A 69.2% were males (n=3468) and 30.8% females (n=1545), with a male to female ratio of 2.2:1. The overall median age at diagnosis was 42 years. Acute myeloid leukemia was most frequent (28.3%) with a median age of 35 years, followed by chronic myeloid leukemia with 18.2% (median age 40 years), non-Hodgkin lymphoma (16.9%; median age 48 years), acute lymphoblastic leukemia (14.1%; median age 27 years), multiple myeloma (10.5%; median age 55 years), myelodysplastic syndromes (4.5%; median age 57 years) and Hodgkin's lymphoma (3.9%; median age 36 years). The least common was chronic lymphocytic leukemia (3.7%; median age 60 years). Below the age of 20 years, acute lymphoblastic leukemia was predominant (37.3%), followed by acute myeloid leukemia (34%). Chronic lymphocytic leukemia and multiple myeloma had mostly occurred among older patients, aged 50-over.
For the first time, our study presents the pattern and distribution of diagnosed hematological cancers in Bangladesh. It shows differences in population distributions as compared to other settings with possibly a lower presence of non-Hodgkin lymphoma. There might be under-reporting of affected women. Further studies are necessary on the epidemiology, genetics and potential environmental risk factors within this rapidly aging country.
癌症的全球负担正在上升，尤其是像孟加拉国这样的低收入国家正经历快速老龄化。到目前为止，尚无全面描述孟加拉国确诊癌症群体（包括血液系统恶性肿瘤）的报告。
这是一项基于多中心医院的回顾性描述性研究，研究对象为2008年1月至2012年12月期间确诊的5000多例血液系统癌症病例。采用“法国-美国-英国”分类系统进行形态学分型。
共有5013例年龄在2至90岁之间的患者被诊断为恶性血液系统疾病。其中男性占69.2%（n = 3468），女性占30.8%（n = 1545），男女比例为2.2:1。诊断时的总体中位年龄为42岁。急性髓系白血病最为常见（28.3%），中位年龄为35岁，其次是慢性髓系白血病，占18.2%（中位年龄40岁），非霍奇金淋巴瘤（16.9%；中位年龄48岁），急性淋巴细胞白血病（14.1%；中位年龄27岁），多发性骨髓瘤（10.5%；中位年龄55岁），骨髓增生异常综合征（4.5%；中位年龄57岁）和霍奇金淋巴瘤（3.9%；中位年龄36岁）。最不常见的是慢性淋巴细胞白血病（3.7%；中位年龄60岁）。20岁以下，急性淋巴细胞白血病占主导（37.3%），其次是急性髓系白血病（34%）。慢性淋巴细胞白血病和多发性骨髓瘤大多发生在50岁以上的老年患者中。
我们的研究首次呈现了孟加拉国确诊血液系统癌症的模式和分布。与其他地区相比显示出人群分布的差异，非霍奇金淋巴瘤的发病率可能较低。可能存在受影响女性报告不足的情况。在这个快速老龄化的国家，有必要对流行病学、遗传学和潜在环境风险因素进行进一步研究。
