孟加拉国确诊的血液系统恶性肿瘤——对10家专科医院5000多例病例的回顾性分析
Diagnosed hematological malignancies in Bangladesh - a retrospective analysis of over 5000 cases from 10 specialized hospitals.
作者信息
Hossain Mohammad Sorowar, Iqbal Mohd S, Khan Mohiuddin Ahmed, Rabbani Mohammad Golam, Khatun Hazera, Munira Sirajam, Miah M Morshed Zaman, Kabir Amin Lutful, Islam Naima, Dipta Tashmim Farhana, Rahman Farzana, Mottalib Abdul, Afrose Salma, Ara Tasneem, Biswas Akhil Ranjan, Rahman Mizanur, Abedin Akm Mustafa, Rahman Mahbubur, Yunus A B M, Niessen Louis W, Sultana Tanvira Afroze
机构信息
BRAC University, Mohakhali, Dhaka, Bangladesh.
出版信息
BMC Cancer. 2014 Jun 14;14:438. doi: 10.1186/1471-2407-14-438.
BACKGROUND
The global burden from cancer is rising, especially as low-income countries like Bangladesh observe rapid aging. So far, there are no comprehensive descriptions reporting diagnosed cancer group that include hematological malignancies in Bangladesh.
METHODS
This was a multi-center hospital-based retrospective descriptive study of over 5000 confirmed hematological cancer cases in between January 2008 to December 2012. Morphological typing was carried out using the "French American British" classification system.
RESULTS
A total of 5013 patients aged between 2 to 90 years had been diagnosed with malignant hematological disorders. A 69.2% were males (n=3468) and 30.8% females (n=1545), with a male to female ratio of 2.2:1. The overall median age at diagnosis was 42 years. Acute myeloid leukemia was most frequent (28.3%) with a median age of 35 years, followed by chronic myeloid leukemia with 18.2% (median age 40 years), non-Hodgkin lymphoma (16.9%; median age 48 years), acute lymphoblastic leukemia (14.1%; median age 27 years), multiple myeloma (10.5%; median age 55 years), myelodysplastic syndromes (4.5%; median age 57 years) and Hodgkin's lymphoma (3.9%; median age 36 years). The least common was chronic lymphocytic leukemia (3.7%; median age 60 years). Below the age of 20 years, acute lymphoblastic leukemia was predominant (37.3%), followed by acute myeloid leukemia (34%). Chronic lymphocytic leukemia and multiple myeloma had mostly occurred among older patients, aged 50-over.
CONCLUSIONS
For the first time, our study presents the pattern and distribution of diagnosed hematological cancers in Bangladesh. It shows differences in population distributions as compared to other settings with possibly a lower presence of non-Hodgkin lymphoma. There might be under-reporting of affected women. Further studies are necessary on the epidemiology, genetics and potential environmental risk factors within this rapidly aging country.
背景
癌症的全球负担正在上升，尤其是像孟加拉国这样的低收入国家正经历快速老龄化。到目前为止，尚无全面描述孟加拉国确诊癌症群体（包括血液系统恶性肿瘤）的报告。
方法
这是一项基于多中心医院的回顾性描述性研究，研究对象为2008年1月至2012年12月期间确诊的5000多例血液系统癌症病例。采用“法国-美国-英国”分类系统进行形态学分型。
结果
共有5013例年龄在2至90岁之间的患者被诊断为恶性血液系统疾病。其中男性占69.2%（n = 3468），女性占30.8%（n = 1545），男女比例为2.2:1。诊断时的总体中位年龄为42岁。急性髓系白血病最为常见（28.3%），中位年龄为35岁，其次是慢性髓系白血病，占18.2%（中位年龄40岁），非霍奇金淋巴瘤（16.9%；中位年龄48岁），急性淋巴细胞白血病（14.1%；中位年龄27岁），多发性骨髓瘤（10.5%；中位年龄55岁），骨髓增生异常综合征（4.5%；中位年龄57岁）和霍奇金淋巴瘤（3.9%；中位年龄36岁）。最不常见的是慢性淋巴细胞白血病（3.7%；中位年龄60岁）。20岁以下，急性淋巴细胞白血病占主导（37.3%），其次是急性髓系白血病（34%）。慢性淋巴细胞白血病和多发性骨髓瘤大多发生在50岁以上的老年患者中。
结论
我们的研究首次呈现了孟加拉国确诊血液系统癌症的模式和分布。与其他地区相比显示出人群分布的差异，非霍奇金淋巴瘤的发病率可能较低。可能存在受影响女性报告不足的情况。在这个快速老龄化的国家，有必要对流行病学、遗传学和潜在环境风险因素进行进一步研究。
Zotero 插件