Baghdadchi Saharnaz, Liu Kimberly, Knapp Jacquelyn, Prager Gabriel, Graves Susannah, Akrami Kevan, Manuel Rolanda, Bastos Rui, Reid Erin, Carson Dennis, Esener Sadik, Carson Joseph, Liu Yu-Tsueng
University of California San Diego, La Jolla, CA, California.
J Transl Med. 2014 Jun 15;12:169. doi: 10.1186/1479-5876-12-169.
Kaposi's sarcoma (KS) is the most frequently occurring cancer in Mozambique among men and the second most frequently occurring cancer among women. Effective therapeutic treatments for KS are poorly understood in this area. There is an unmet need to develop a simple but accurate tool for improved monitoring and diagnosis in a resource-limited setting. Standardized clinical photographs have been considered to be an essential part of the evaluation.
When a therapeutic response is achieved, nodular KS often exhibits a reduction of the thickness without a change in the base area of the lesion. To evaluate the vertical space along with other characters of a KS lesion, we have created an innovative imaging system with a consumer light-field camera attached to a miniature "photography studio" adaptor. The image file can be further processed by computational methods for quantification.
With this novel imaging system, each high-quality 3D image was consistently obtained with a single camera shot at bedside by minimally trained personnel. After computational processing, all-focused photos and measurable 3D parameters were obtained. More than 80 KS image sets were processed in a semi-automated fashion.
In this proof-of-concept study, the feasibility to use a simple, low-cost and user-friendly system has been established for future clinical study to monitor KS therapeutic response. This 3D imaging system can be also applied to obtain standardized clinical photographs for other diseases.
卡波西肉瘤（KS）是莫桑比克男性中最常见的癌症，在女性中是第二常见的癌症。在该地区，对KS有效的治疗方法了解甚少。在资源有限的环境中，迫切需要开发一种简单而准确的工具来改善监测和诊断。标准化临床照片已被视为评估的重要组成部分。
当达到治疗反应时，结节性KS通常表现为厚度减小而病变基面积不变。为了评估KS病变的垂直空间以及其他特征，我们创建了一种创新的成像系统，该系统将消费级光场相机连接到微型“摄影工作室”适配器上。图像文件可以通过计算方法进一步处理以进行量化。
使用这种新颖的成像系统，经过最少培训的人员在床边用单张相机拍摄就能始终获得高质量的3D图像。经过计算处理后，获得了全聚焦照片和可测量的3D参数。以半自动方式处理了80多个KS图像集。
在这项概念验证研究中，已证明使用简单、低成本且用户友好的系统用于未来临床研究以监测KS治疗反应的可行性。这种3D成像系统也可用于获取其他疾病的标准化临床照片。
