Zalla M J
Department of Dermatology, Mayo Clinic Scottsdate, AZ 85259, USA.
Dermatol Surg. 1996 Mar;22(3):274-87.
Kaposi's sarcoma (KS) had been an uncommon entity prior to the outbreak of the AIDS epidemic but is now the most common neoplasm occurring in patient's with AIDS. KS occurs in four distinct subsets, each of which the dermatologist is well suited to diagnose and manage. Significant advances have been made recently related to the etiology of KS and new options for treatment.
The purpose of this paper is to update clinicians on the diagnosis, etiology, and treatment of KS.
Articles from the recent dermatologic and nondermatologic literature have been reviewed and summarized.
The clinical features of the four subsets of KS are presented. Recent evidence reveals a close association between KS and a new human herpesvirus, termed Kaposi's sarcoma-associated herpesvirus (KSHV), in all subsets of KS. KSHV may play an etiologic role in the development of some cases of KS. Treatment options include local destructive measures and systemic regimens, the choice of which is based on extent of disease, symptomatology, degree of immunosuppression, and concurrent medical problems. New treatments aimed at factors involved in the pathogenesis of KS may provide additional options for the future.
KS is a disease well suited to diagnosis and management by dermatologists. As more is learned of its etiology and pathogenesis, new therapeutic approaches will continue to be developed.
在艾滋病流行爆发之前，卡波西肉瘤（KS）是一种罕见的疾病，但现在是艾滋病患者中最常见的肿瘤。KS有四种不同的类型，皮肤科医生非常适合对每一种类型进行诊断和管理。最近在KS的病因学和新的治疗选择方面取得了重大进展。
本文旨在向临床医生介绍KS的诊断、病因和治疗方面的最新情况。
对近期皮肤科和非皮肤科文献中的文章进行了综述和总结。
介绍了KS四种类型的临床特征。最近的证据表明，在KS的所有类型中，KS与一种新的人类疱疹病毒——卡波西肉瘤相关疱疹病毒（KSHV）密切相关。KSHV可能在某些KS病例的发生中起病因学作用。治疗选择包括局部破坏措施和全身治疗方案，其选择基于疾病的范围、症状、免疫抑制程度和并发的医疗问题。针对KS发病机制中涉及的因素的新治疗方法可能为未来提供更多选择。
KS是一种非常适合皮肤科医生进行诊断和管理的疾病。随着对其病因和发病机制的了解越来越多，新的治疗方法将不断被开发出来。
