Gilmartin Marieke R, Balderston Nicholas L, Helmstetter Fred J
Department of Psychology, University of Wisconsin-Milwaukee, 2441 E. Hartford Ave., Milwaukee, WI 53211, USA; Department of Biomedical Sciences, Marquette University, 561 N 15th Street, Milwaukee, WI 53233, USA.
Department of Psychology, University of Wisconsin-Milwaukee, 2441 E. Hartford Ave., Milwaukee, WI 53211, USA.
Trends Neurosci. 2014 Aug;37(8):455-64. doi: 10.1016/j.tins.2014.05.004. Epub 2014 Jun 11.
The prefrontal cortex regulates the expression of fear based on previously learned information. Recently, this brain area has emerged as being crucial in the initial formation of fear memories, providing new avenues to study the neurobiology underlying aberrant learning in anxiety disorders. Here we review the circumstances under which the prefrontal cortex is recruited in the formation of memory, highlighting relevant work in laboratory animals and human subjects. We propose that the prefrontal cortex facilitates fear memory through the integration of sensory and emotional signals and through the coordination of memory storage in an amygdala-based network.
前额叶皮层根据先前学到的信息调节恐惧的表达。最近，这个脑区已成为恐惧记忆最初形成过程中的关键区域，为研究焦虑症中异常学习背后的神经生物学提供了新途径。在这里，我们回顾前额叶皮层在记忆形成过程中被激活的情况，重点介绍实验动物和人类受试者的相关研究。我们认为，前额叶皮层通过整合感觉和情绪信号以及协调杏仁核网络中的记忆存储来促进恐惧记忆。
