Heideman Simone G, te Woerd Erik S, Praamstra Peter
Department of Neurology, RadboudUMC, Radboud University Nijmegen, Netherlands; Donders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen, Netherlands; Oxford Centre for Human Brain Activity, Dept. of Psychiatry, Warneford Hospital, Oxford, UK.
Department of Neurology, RadboudUMC, Radboud University Nijmegen, Netherlands; Donders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen, Netherlands.
Clin Neurophysiol. 2015 Feb;126(2):348-55. doi: 10.1016/j.clinph.2014.04.020. Epub 2014 May 24.
The time course of the contingent negative variation (CNV) as well as beta-power are known to entrain to regular task rhythms, revealing implicit anticipatory timing. Thus far, these effects have been established for manual responses only. Here we investigate entrainment preceding leg movements.
High-density EEG was recorded while participants were standing and responded to series of rhythmically presented arrow stimuli by making brisk leg movements. The standard interval between reaction stimuli differed between series and was either 1500 or 2000 ms. Each series' final interval was 1750 ms, representing a timing perturbation.
Entrainment was manifested in the CNV time course, where the maximum amplitude was reached just before the next stimulus was presented. The pattern of beta-(de)synchronization similarly entrained to the task rhythm. CNV scalp topographies suggested effector dependency of the entrainment-induced CNV.
We demonstrate that lower limb motor control, like upper limb control, readily entrains to a regular task rhythm.
These findings are relevant to Parkinson's disease (PD), where problems are found in rhythm processing and temporal preparation. Investigation of the neural correlates of leg movement entrainment is important in view of presumed relations between entrainment and cueing of gait in PD.
已知关联性负变（CNV）的时间进程以及β波功率会与常规任务节奏同步，揭示出内隐的预期定时。到目前为止，这些效应仅在手动反应中得到证实。在此，我们研究腿部运动之前的同步情况。
在参与者站立并通过轻快的腿部运动对一系列有节奏呈现的箭头刺激做出反应时，记录高密度脑电图（EEG）。反应刺激之间的标准间隔在各系列中有所不同，为1500或2000毫秒。每个系列的最后一个间隔为1750毫秒，代表定时扰动。
同步表现在CNV的时间进程中，在下一个刺激出现之前达到最大振幅。β波（去）同步模式同样与任务节奏同步。CNV头皮地形图表明同步诱导的CNV存在效应器依赖性。
我们证明，下肢运动控制与上肢控制一样，容易与常规任务节奏同步。
这些发现与帕金森病（PD）相关，在PD中，节律处理和时间准备方面存在问题。鉴于同步与PD中步态提示之间的假定关系，研究腿部运动同步的神经相关性很重要。
