Rostand Stephen G
The Nephrology Research and Training Center, Division of Nephrology, Department of Medicine, The University of Alabama at Birmingham, 266 Paula Building, 1720 2nd Avenue South, Birmingham, AL, 35294, USA,
Curr Hypertens Rep. 2014 Aug;16(8):464. doi: 10.1007/s11906-014-0464-6.
Vitamin D deficiency is inversely associated with blood pressure and is felt to contribute to the genesis and maintenance of hypertension. Although well demonstrated in animal studies, in many clinical studies the association between vitamin D status and blood pressure has not been consistently observed or else has been quite small. These discrepancies may relate in part to methodological differences including: patient selection, study size and duration, and, in the case of vitamin D repletion studies, differences in the vitamin D supplement used, its dose, and dosing intervals. Polymorphisms in genes regulating vitamin D activation and function may explain some of the observed inconsistencies as suggested by recent studies. The present review examines experimental and clinical studies bearing on the inverse association between blood pressure and vitamin D status and concludes that a new definition of vitamin D deficiency using additional biomarkers may better select patients with hypertension who will respond to vitamin D supplementation.
维生素D缺乏与血压呈负相关，被认为与高血压的发生和维持有关。尽管在动物研究中已得到充分证实，但在许多临床研究中，维生素D状态与血压之间的关联并未得到一致观察，或者关联非常小。这些差异可能部分与方法学差异有关，包括：患者选择、研究规模和持续时间，以及在维生素D补充研究中，所使用的维生素D补充剂、剂量和给药间隔的差异。如最近的研究所表明的，调节维生素D激活和功能的基因多态性可能解释一些观察到的不一致情况。本综述研究了与血压和维生素D状态之间的负相关有关的实验和临床研究，并得出结论，使用额外生物标志物对维生素D缺乏进行新的定义，可能会更好地筛选出对维生素D补充有反应的高血压患者。
