植物化学物质：对抗胃癌的潜在抗癌剂。

Plant phytochemicals: potential anticancer agents against gastric cancer.

作者信息

Øverby Anders, Zhao Chun-Mei, Chen Duan

机构信息

Department of Biology, Norwegian University of Science and Technology, Høgskoleringen 5, N-7491 Trondheim, Norway; Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, N-7034 Trondheim, Norway.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, N-7034 Trondheim, Norway.

出版信息

Curr Opin Pharmacol. 2014 Dec;19:6-10. doi: 10.1016/j.coph.2014.05.010. Epub 2014 Jun 12.

DOI:10.1016/j.coph.2014.05.010

PMID:24929966

Abstract

Isothiocyanates (ITCs) are plant phytochemicals derived from vegetables consumed by human. ITCs comprise potent anti-carcinogenic agents of which the consumption has been linked to a reduced risk of cancer at several locations in the body. However, the studies on coping with gastric cancer remain unsatisfied. In the present review, ITCs are discussed in this context as ITCs may target gastric tumorigenesis at multiple levels. ITCs are taken up in the stomach, exposing mucosal and muscle layer cells as well as affecting Helicobacter pylori residing in the stomach. The natural and potent anti-cancer ITCs from vegetables have a great potential against gastric cancer, a disease in need of new treatment or preventive modalities.

摘要

异硫氰酸盐（ITCs）是人类食用蔬菜中含有的植物性化学物质。ITCs包含强效抗癌剂，食用这些物质与降低身体多个部位患癌风险有关。然而，关于应对胃癌的研究仍不尽人意。在本综述中，将在这种背景下讨论ITCs，因为ITCs可能在多个层面靶向胃癌的发生。ITCs在胃中被吸收，会接触到黏膜和肌层细胞，并影响胃内的幽门螺杆菌。蔬菜中天然且强效的抗癌ITCs对胃癌具有巨大潜力，而胃癌是一种需要新的治疗或预防方法的疾病。