Institute of Nutritional Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
Int J Mol Sci. 2017 Sep 1;18(9):1890. doi: 10.3390/ijms18091890.
A high consumption of vegetables belonging to the family has been related to a lower incidence of chronic diseases including different kinds of cancer. These beneficial effects of, e.g., broccoli, cabbage or rocket (arugula) intake have been mainly dedicated to the sulfur-containing glucosinolates (GLSs)-secondary plant compounds nearly exclusively present in and in particular to their bioactive breakdown products including isothiocyanates (ITCs). Overall, the current literature indicate that selected -derived ITCs exhibit health-promoting effects in vitro, as well as in laboratory mice in vivo. Some studies suggest anti-carcinogenic and anti-inflammatory properties for ITCs which may be communicated through an activation of the redox-sensitive transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) that controls the expression of antioxidant and phase II enzymes. Furthermore, it has been shown that ITCs are able to significantly ameliorate a severe inflammatory phenotype in colitic mice in vivo. As there are studies available suggesting an epigenetic mode of action for -derived phytochemicals, the conduction of further studies would be recommendable to investigate if the beneficial effects of these compounds also persist during an irregular consumption pattern.
大量食用十字花科蔬菜与较低的慢性病发病率有关，包括各种癌症。这些有益的效果，例如，西兰花、白菜或芝麻菜（火箭菜）的摄入，主要归因于含硫的硫代葡萄糖苷（GLS）——几乎只存在于十字花科蔬菜中的次生植物化合物，特别是它们的生物活性分解产物，包括异硫氰酸盐（ITC）。总的来说，目前的文献表明，一些特定的 - 衍生的 ITC 在体外以及在实验室小鼠体内具有促进健康的作用。一些研究表明，ITC 具有抗癌和抗炎特性，可能通过激活氧化还原敏感的转录因子核因子红细胞 2 相关因子 2（Nrf2）来传递，Nrf2 控制抗氧化剂和 II 相酶的表达。此外，已经表明 ITC 能够显著改善结肠炎小鼠体内的严重炎症表型。由于有研究表明 - 衍生的植物化学物质具有表观遗传作用模式，因此建议进行进一步的研究，以调查这些化合物的有益效果是否在不规则的消费模式下仍然存在。
