Aibaidula Abudumijiti, Lu Jun-feng, Wu Jin-song, Zou He-jian, Chen Hong, Wang Yu-qian, Qin Zhi-yong, Yao Yu, Gong Ye, Che Xiao-ming, Zhong Ping, Li Shi-qi, Bao Wei-min, Mao Ying, Zhou Liang-fu
Glioma Surgery Division, Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.
Cell Tissue Bank. 2015 Jun;16(2):271-81. doi: 10.1007/s10561-014-9459-4. Epub 2014 Jun 15.
Cerebral glioma is the most common brain tumor as well as one of the top ten malignant tumors in human beings. In spite of the great progress on chemotherapy and radiotherapy as well as the surgery strategies during the past decades, the mortality and morbidity are still high. One of the major challenges is to explore the pathogenesis and invasion of glioma at various "omics" levels (such as proteomics or genomics) and the clinical implications of biomarkers for diagnosis, prognosis or treatment of glioma patients. Establishment of a standardized tissue bank with high quality biospecimens annotated with clinical information is pivotal to the solution of these questions as well as the drug development process and translational research on glioma. Therefore, based on previous experience of tissue banks, standardized protocols for sample collection and storage were developed. We also developed two systems for glioma patient and sample management, a local database for medical records and a local image database for medical images. For future set-up of a regional biobank network in Shanghai, we also founded a centralized database for medical records. Hence we established a standardized glioma tissue bank with sufficient clinical data and medical images in Huashan Hospital. By September, 2013, tissues samples from 1,326 cases were collected. Histological diagnosis revealed that 73 % were astrocytic tumors, 17 % were oligodendroglial tumors, 2 % were oligoastrocytic tumors, 4 % were ependymal tumors and 4 % were other central nervous system neoplasms.
脑胶质瘤是最常见的脑部肿瘤，也是人类十大恶性肿瘤之一。尽管在过去几十年里化疗、放疗以及手术策略取得了巨大进展，但死亡率和发病率仍然很高。主要挑战之一是在各种“组学”水平（如蛋白质组学或基因组学）上探索胶质瘤的发病机制和侵袭情况，以及生物标志物对胶质瘤患者诊断、预后或治疗的临床意义。建立一个带有高质量生物样本并标注有临床信息的标准化组织库，对于解决这些问题以及胶质瘤的药物研发过程和转化研究至关重要。因此，基于以往组织库的经验，制定了样本采集和存储的标准化方案。我们还开发了两个用于胶质瘤患者和样本管理的系统，一个用于病历的本地数据库和一个用于医学图像的本地图像数据库。为了未来在上海建立区域生物样本库网络，我们还建立了一个集中的病历数据库。因此，我们在华山医院建立了一个拥有充足临床数据和医学图像的标准化胶质瘤组织库。截至2013年9月，共采集了1326例患者的组织样本。组织学诊断显示，73%为星形细胞瘤，17%为少突胶质细胞瘤，2%为少突星形细胞瘤，4%为室管膜瘤，4%为其他中枢神经系统肿瘤。
