Coolens J L, Heyns W
Department of Endocrinology and Isotopes, Salvatorziekenhuis, Hasselt, Belgium.
J Clin Endocrinol Metab. 1989 Feb;68(2):492-4. doi: 10.1210/jcem-68-2-492.
Unexplained high serum corticosteroid-binding globulin (CBG) concentrations [mean values, 78.8 and 55.7 mg/L; normal women, 38.8 +/- 3.8 (+/- SD) mg/L] were found repeatedly in two apparently healthy sisters who were not pregnant or taking exogenous estrogens. One had substantial variations in serum CBG and sex hormone-binding globulin concentrations during the menstrual cycle, which paralleled the normal cyclic changes in serum estradiol. The other woman was postmenopausal and had a high serum CBG concentration despite of low serum estradiol levels. We conclude those women have an inherited abnormality in CBG production.
在两名显然健康、未怀孕且未服用外源性雌激素的姐妹中，反复发现不明原因的高血清皮质类固醇结合球蛋白（CBG）浓度[平均值分别为78.8和55.7 mg/L；正常女性为38.8±3.8（±标准差）mg/L]。其中一人在月经周期中血清CBG和性激素结合球蛋白浓度有显著变化，这与血清雌二醇的正常周期性变化平行。另一女性已绝经，尽管血清雌二醇水平较低，但血清CBG浓度仍很高。我们得出结论，这些女性在CBG产生方面存在遗传性异常。
