Lapidus L, Lindstedt G, Lundberg P A, Bengtsson C, Gredmark T
Clin Chem. 1986 Jan;32(1 Pt 1):146-52.
We determined sex-hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) by radioimmunoassay of serum samples from a group of 253 women, who were 54 or 60 years old when first studied in 1968-69. The SHBG concentration was highly significantly and inversely related to body mass, body mass index, waist-to-hip circumference ratio, and serum triglyceride concentration; CBG concentration was inversely related to body mass and body mass index. The concentration of neither protein was related to whether or not the subject smoked. Decrease in the concentration of SHBG, but not of CBG, was a significant risk factor for 12-year overall mortality. The plot of the 12-year incidence of myocardial infarction vs SHBG concentration was U-shaped. We recommend that SHBG be included when serum androgens or estrogens are being evaluated as risk factors for cardiovascular disease and death.
我们通过放射免疫分析法测定了一组253名女性血清样本中的性激素结合球蛋白（SHBG）和皮质类固醇结合球蛋白（CBG）。这些女性在1968 - 1969年首次接受研究时年龄为54岁或60岁。SHBG浓度与体重、体重指数、腰臀围比以及血清甘油三酯浓度呈高度显著的负相关；CBG浓度与体重和体重指数呈负相关。两种蛋白质的浓度均与受试者是否吸烟无关。SHBG浓度降低是12年总死亡率的一个显著危险因素，而CBG浓度降低则不是。心肌梗死12年发病率与SHBG浓度的关系曲线呈U形。我们建议，在评估血清雄激素或雌激素作为心血管疾病和死亡的危险因素时，应纳入SHBG。
