Nikzad Sonia, Tan Soon Guan, Yong Seok Yien Christina, Ng Jillian, Alitheen Noorjahan Banu, Khan Razib, Rovie-Ryan Jeffrine J, Valdiani Alireza, Khajeaian Parastoo, Kanthaswamy Sree
Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Malaysia.
J Med Primatol. 2014 Dec;43(6):433-44. doi: 10.1111/jmp.12130. Epub 2014 Jun 16.
The genetic diversity and structure of long-tailed macaques (Macaca fascicularis) in Peninsular Malaysia, a widely used non-human primate species in biomedical research, have not been thoroughly characterized.
Thirteen sites of wild populations of long-tailed macaques representing six states were sampled and analyzed with 18 STR markers.
The Sunggala and Penang Island populations showed the highest genetic diversity estimates, while the Jerejak Island population was the most genetically discrete due to isolation from the mainland shelf. Concordant with pairwise F(st) estimates, STRUCTURE analyses of the seven PCA-correlated clusters revealed low to moderate differentiation among the sampling sites. No association between geographic and genetic distances exists, suggesting that the study sites, including island study sites, are genetically if not geographically contiguous.
The status of the genetic structure and composition of long-tailed macaque populations require further scrutiny to develop this species as an important animal model in biomedical research.
长尾猕猴（食蟹猴）是生物医学研究中广泛使用的非人灵长类动物物种，其在马来西亚半岛的遗传多样性和结构尚未得到充分表征。
对代表六个州的13个长尾猕猴野生种群地点进行采样，并使用18个STR标记进行分析。
Sungguala和槟城岛种群的遗传多样性估计值最高，而Jerejak岛种群由于与大陆架隔离，在遗传上最为离散。与成对Fst估计值一致，对七个主成分分析相关聚类的STRUCTURE分析显示，采样地点之间存在低到中等程度的分化。地理距离与遗传距离之间不存在关联，这表明包括岛屿研究地点在内的研究地点在遗传上（即使在地理上不）是相邻的。
长尾猕猴种群的遗传结构和组成状况需要进一步审查，以便将该物种发展成为生物医学研究中的重要动物模型。
