van Gastel W A, Vreeker A, Schubart C D, MacCabe J H, Kahn R S, Boks M P M
Brain Center Rudolf Magnus, University Medical Center Utrecht, Department of Psychiatry, HP. B01.206, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands; Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; Department of Sexology & Psychosomatic Obstetrics and Gynaecology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
Brain Center Rudolf Magnus, University Medical Center Utrecht, Department of Psychiatry, HP. B01.206, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Schizophr Res. 2014 Aug;157(1-3):266-70. doi: 10.1016/j.schres.2014.04.023. Epub 2014 Jun 12.
To prospectively assess the relationship between cannabis use and psychotic experiences over time.
In a longitudinal design, young adults aged 18-27years (N=705) gave online information on cannabis use and completed the Community Assessment of Psychic Experiences (CAPE). These measures were repeated after an interval ranging from six months to five years.
A decrease in cannabis use was associated with a decrease in total psychotic experiences (β=-0.096, p=0.01) after adjustment for a range of potential confounders. An increase in cannabis use was associated with increased positive symptoms at follow-up (β=0.07, p=0.02), but was not significantly associated with increases in Negative and Depression symptom scores, nor with the total number of psychotic experiences.
In the first study to the association of change in cannabis use and psychotic experiences over time in the general population, we found an association between changes in cannabis use and changes in the frequency of psychotic experiences. While this does not prove a causal relationship between cannabis use and psychosis, our findings are consistent with studies suggesting that cessation of cannabis use may be beneficial in terms of reducing psychotic experiences.
前瞻性评估长期使用大麻与精神病体验之间的关系。
采用纵向设计，18至27岁的年轻人（N = 705）在线提供大麻使用信息，并完成了精神体验社区评估（CAPE）。在六个月至五年的间隔后重复这些测量。
在调整一系列潜在混杂因素后，大麻使用量的减少与总的精神病体验减少相关（β=-0.096，p = 0.01）。随访时大麻使用量的增加与阳性症状增加相关（β= 0.07，p = 0.02），但与阴性和抑郁症状评分的增加以及精神病体验的总数无显著关联。
在第一项关于普通人群中随时间变化的大麻使用与精神病体验之间关联的研究中，我们发现大麻使用的变化与精神病体验频率的变化之间存在关联。虽然这并未证明大麻使用与精神病之间存在因果关系，但我们的研究结果与表明停止使用大麻可能有利于减少精神病体验的研究一致。
