Dai Weili, Ge Wentong, Zhang Jie, Zhang Yamei
Department of Otorhinolaryngology, Beijing Children's Hospital Affiliated to Capital University of Medical Sciences, Beijing Pediatric Research Institute, Beijing Key Laboratory for Pediatric Diseases of Otorhinolaryngology, Head and Neck Surgery, Beijing 100045, China.
Department of Otorhinolaryngology, Beijing Children's Hospital Affiliated to Capital University of Medical Sciences, Beijing Pediatric Research Institute, Beijing Key Laboratory for Pediatric Diseases of Otorhinolaryngology, Head and Neck Surgery, Beijing 100045, China. Email:
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Apr;49(4):277-82.
To study the high risk factors of allergen sensitization among 1-16 years old children with allergic rhinitis (AR) symptoms.
Medical history was collected from 518 children with AR symptoms aged 1 to 16 years old between April 2011 and November 2012, including five aspects:basic information, disease characteristics, associated with other allergic diseases, growth and development history and genetic history and so on. The allergens were determined by UniCAP 100 system. The high risk factors of allergen sensitization (sIgE ≥ grade III) among 1-16 years old children with AR symptoms were analyzed. The data processing and statistical analysis were conducted by SPSS 17.0 software.
Three hundred and thirty of 518 patients (63.7%) could be diagnosed as AR. The primary allergen was mixed fungal (52.4%). The highest percentage of allergen sIgE ≥ grade III accounted for the corresponding allergen positive cases was 71.1% (mixed fungal). Single factor analysis of clinical characteristics in the groups of AR and non AR showed that the history of months(χ(2) = -3.591), concomitant allergic conjunctivitis (χ(2) = 12.325) and cats or dogs at home (χ(2) = 5.615) were statistically significant between the two groups (all P < 0.05).In children with AR, single factor analysis of clinical characteristics in the groups of whether positive allergen level ≥ grade III showed that the concomitant asthma(χ(2) = 4.097), breastfeeding(χ(2) = 4.186), the housing situation (χ(2) = 4.360) and the bedroom toward (χ(2) = 4.656) were statistically significant between the two groups (all P < 0.05). In children with AR, single factor analysis of clinical characteristics in different age groups showed that the history of months(χ(2) = 64.999), concomitant eczema (χ(2) = 24.056), concomitant insect bite dermatitis (χ(2) = 9.148), cats or dogs at home (χ(2) = 8.529) and mother suffered from AR (χ(2) = 9.565) were statistically significant in different age groups (all P < 0.05).
The study revealed that the longer of history, concomitant allergic conjunctivitis and cats or dogs at home are risk factors for AR;In children with AR, not breastfeeding and the bedroom toward back are risk factors for inhalation allergen sIgE ≥ gradeIII.
研究1 - 16岁有过敏性鼻炎（AR）症状儿童过敏原致敏的高危因素。
收集2011年4月至2012年11月期间518例1至16岁有AR症状儿童的病史，包括五个方面：基本信息、疾病特征、与其他过敏性疾病的关联、生长发育史和遗传史等。采用UniCAP 100系统测定过敏原。分析1 - 16岁有AR症状儿童过敏原致敏（sIgE≥Ⅲ级）的高危因素。数据处理和统计分析采用SPSS 17.0软件。
518例患者中有330例（63.7%）可诊断为AR。主要过敏原为混合真菌（52.4%）。过敏原sIgE≥Ⅲ级占相应过敏原阳性病例的最高百分比为71.1%（混合真菌）。AR组和非AR组临床特征的单因素分析显示，病程月数（χ(2)= -3.591）、合并过敏性结膜炎（χ(2)= 12.325）和家中养猫或狗（χ(2)= 5.615）在两组间差异有统计学意义（均P < 0.05）。在AR儿童中，过敏原水平≥Ⅲ级与否的组间临床特征单因素分析显示，合并哮喘（χ(2)= 4.097）、母乳喂养情况（χ(2)= 4.186）、居住状况（χ(2)= 4.360）和卧室朝向（χ(2)= 4.656）在两组间差异有统计学意义（均P < 0.05）。在AR儿童中，不同年龄组临床特征的单因素分析显示，病程月数（χ(2)= 64.999）、合并湿疹（χ(2)= 24.056）、合并虫咬性皮炎（χ(2)= 9.148）、家中养猫或狗（χ(2)= 8.529）和母亲患AR（χ(2)= 9.565）在不同年龄组间差异有统计学意义（均P < 0.05）。
研究表明，病程越长、合并过敏性结膜炎和家中养猫或狗是AR的危险因素；在AR儿童中，非母乳喂养和卧室朝向后是吸入性过敏原sIgE≥Ⅲ级的危险因素。
