Zhu Kang, Hou Xiao-Ling, Huang Hui-Jie, Wang Ya-Ru, Ren Yi-Xin, Ni Xin, Xiang Li
Department of Allergy, Beijing Children's Hospital, Capital Medical University/National Center for Children's Health, Beijing 100045, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2017 Nov;19(11):1185-1190. doi: 10.7499/j.issn.1008-8830.2017.11.012.
To investigate the distribution characteristics of serum specific IgE (sIgE) for inhaled allergens in children with different airway allergic diseases.
Fluorescent enzyme-linked immunosorbent assay on the UniCAP250 system was performed to measure serum sIgE for 9 common inhaled allergens in 256 children aged 3-14 years with different airway allergic diseases. According to the clinical diagnosis, these children were divided into rhinitis group (37 children with allergic rhinitis), asthma group (82 children with bronchial asthma), and rhinitis-asthma group (137 children with allergic rhinitis complicated by bronchial asthma). The three groups were compared in terms of the detection rates of 9 inhaled allergens, sensitization level, and number of allergens.
The detection rate of serum sIgE for inhaled allergens was 57.3% (47/82) in the asthma group, 86.5% (32/37) in the rhinitis group, and 82.5% (113/137) in the rhinitis-asthma group (P<0.05). The most common allergen in the asthma, rhinitis, and the rhinitis-asthma groups was mould fungi (32.9%, 54.1%, and 48.9% respectively), followed by dust mites (30.5%, 45.9%, and 46.0% respectively), pollen (26.8%, 35.1%, and 32.8% respectively), pets (12.2%, 27.0%, and 18.2% respectively), and cockroach (9.8%, 5.4%, and 5.8% respectively). The rhinitis group and the rhinitis-asthma group had a significantly higher detection rate of mould fungi (mx2) than the asthma group (P<0.0166). There were no significant differences in the sensitization level of 9 allergens and number of allergens between the three groups.
In children with either bronchial asthma, allergic rhinitis, or bronchial asthma complicated by allergic rhinitis, the three most common inhaled allergens are mould fungi, dust mites, and pollens. Compared with bronchial asthma, allergic rhinitis may be more closely associated with sensitization by mould fungi. The three common airway allergic diseases have similar distribution characteristics of inhaled allergens.
探讨不同气道过敏性疾病患儿吸入性变应原血清特异性IgE（sIgE）的分布特征。
采用UniCAP250系统上的荧光酶联免疫吸附测定法，检测256例3 - 14岁患有不同气道过敏性疾病患儿血清中9种常见吸入性变应原的sIgE。根据临床诊断，将这些患儿分为鼻炎组（37例过敏性鼻炎患儿）、哮喘组（82例支气管哮喘患儿）和鼻炎 - 哮喘组（137例过敏性鼻炎合并支气管哮喘患儿）。比较三组9种吸入性变应原的检出率、致敏水平及变应原种类数。
哮喘组吸入性变应原血清sIgE检出率为57.3%（47/82），鼻炎组为86.5%（32/37），鼻炎 - 哮喘组为82.5%（113/137）（P<0.05）。哮喘组、鼻炎组和鼻炎 - 哮喘组最常见的变应原均为霉菌（分别为32.9%、54.1%和48.9%），其次为尘螨（分别为30.5%、45.9%和46.0%）、花粉（分别为26.8%、35.1%和32.8%）、宠物（分别为12.2%、27.0%和18.2%）、蟑螂（分别为9.8%、5.4%和5.8%）。鼻炎组和鼻炎 - 哮喘组霉菌（mx2）的检出率显著高于哮喘组（P<0.0166）。三组9种变应原的致敏水平及变应原种类数无显著差异。
在患有支气管哮喘、过敏性鼻炎或过敏性鼻炎合并支气管哮喘的患儿中，三种最常见的吸入性变应原是霉菌、尘螨和花粉。与支气管哮喘相比，过敏性鼻炎可能与霉菌致敏关系更密切。三种常见的气道过敏性疾病具有相似的吸入性变应原分布特征。
