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足背S100A6和c-Kit阳性梭形细胞黑色素瘤

S100A6 and c-Kit-Positive Spindle Cell Melanoma of the Dorsal Foot.

作者信息

Mitamura Yasutaka, Ito Takamichi, Nakano-Nakamura Misa, Uchi Hiroshi, Furue Masutaka

机构信息

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

出版信息

Case Rep Dermatol. 2014 May 16;6(2):140-4. doi: 10.1159/000363097. eCollection 2014 May.

DOI:10.1159/000363097
PMID:24932168
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4049021/
Abstract

Spindle cell melanoma, which is a rare form of melanoma, is clinically and histopathologically difficult to diagnose from a variety of nonmelanocytic spindle cell tumors. We describe a 42-year-old Japanese woman with amelanotic melanoma that comprised spindle cells with positive c-kit and S100A6 staining. The use of c-kit and S100A6 might be useful for improving the diagnosis.

摘要

梭形细胞黑色素瘤是黑色素瘤的一种罕见形式,在临床和组织病理学上很难与多种非黑色素细胞性梭形细胞瘤相鉴别。我们描述了一名42岁的日本女性,其无色素性黑色素瘤由c-kit和S100A6染色阳性的梭形细胞组成。使用c-kit和S100A6可能有助于提高诊断水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/4049021/761c8c0455fd/cde-0006-0140-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/4049021/add6242ba38e/cde-0006-0140-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/4049021/761c8c0455fd/cde-0006-0140-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/4049021/add6242ba38e/cde-0006-0140-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a8a/4049021/761c8c0455fd/cde-0006-0140-g02.jpg

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本文引用的文献

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A diagnostic algorithm to distinguish desmoplastic from spindle cell melanoma.一种用于鉴别促结缔组织增生型与梭形细胞黑素瘤的诊断算法。
Mod Pathol. 2014 Apr;27(4):524-34. doi: 10.1038/modpathol.2013.162. Epub 2013 Sep 20.
2
Aberrant expression of S100A6 and matrix metalloproteinase 9, but not S100A2, S100A4, and S100A7, is associated with epidermal carcinogenesis.S100A6 和基质金属蛋白酶 9 的异常表达与表皮癌发生有关,但 S100A2、S100A4 和 S100A7 则不然。
J Dermatol Sci. 2013 Dec;72(3):311-9. doi: 10.1016/j.jdermsci.2013.07.005. Epub 2013 Aug 8.
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Desmoplastic melanoma: a review.
Biomolecules. 2023 Jul 17;13(7):1139. doi: 10.3390/biom13071139.
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RAGE Signaling in Melanoma Tumors.RAGE 信号在黑素瘤肿瘤中的作用。
Int J Mol Sci. 2020 Nov 26;21(23):8989. doi: 10.3390/ijms21238989.
促结缔组织增生性黑色素瘤:综述。
J Am Acad Dermatol. 2013 May;68(5):825-33. doi: 10.1016/j.jaad.2012.10.041. Epub 2012 Dec 23.
4
Amelanotic melanoma: a detailed morphologic analysis with clinicopathologic correlation of 75 cases.无色素性黑色素瘤:75例临床病理相关性的详细形态学分析
J Cutan Pathol. 2012 Jan;39(1):33-9. doi: 10.1111/j.1600-0560.2011.01808.x. Epub 2011 Nov 3.
5
Atypical fibroxanthoma.非典型性纤维黄色瘤
Clin Med Oncol. 2008;2:117-27. doi: 10.4137/cmo.s506. Epub 2008 Feb 9.
6
The staining pattern of pigmented spindle cell nevi with S100A6 protein.色素性梭形细胞痣的S100A6蛋白染色模式。
J Cutan Pathol. 2011 Jan;38(1):14-7. doi: 10.1111/j.1600-0560.2010.01624.x. Epub 2010 Oct 5.
7
S100A6 - new facts and features.S100A6——新的事实和特征。
Biochem Biophys Res Commun. 2009 Dec 25;390(4):1087-92. doi: 10.1016/j.bbrc.2009.10.150. Epub 2009 Nov 3.
8
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J Cutan Pathol. 2008 Nov;35 Suppl 2:28-34. doi: 10.1111/j.1600-0560.2007.00866.x. Epub 2008 Jan 14.
9
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Mod Pathol. 2003 May;16(5):505-11. doi: 10.1097/01.MP.0000071128.67149.FD.