Kumar Vijay, Shahi Ashish Kumar
Department of Oral and Maxillofacial Surgery, R. D. Dental Hospital and Research Centre, Patna, Bihar, India.
Consultant Oral and Maxillofacial Surgeon, Gorakhpur, U.P., India.
Dent Res J (Isfahan). 2014 Mar;11(2):147-53.
Nitrogen containing bisphosphonate (N-BP) therapy is used extensively to treat osteoporosis and osteolytic bone lesions. Recently, a special form of osteonecrosis limited to the maxillofacial skeleton has been discovered especially within those patients who are receiving either long-term N-BP therapy alone and/or associated with invasive dental procedure. Bisphosphonates accumulate almost exclusively in maxillofacial skeleton owing to high bone turn over remodeling to maintain the mechanical competence. The pathogenesis and why it commonly appears in maxillofacial skeleton and the fixed treatment strategies remains unknown. The aim of this study was to improve the clinician understanding of N-BPs associated osteonecrosis of maxillofacial skeleton by reviewing the past 10 year literature.
含氮双膦酸盐（N-BP）疗法被广泛用于治疗骨质疏松症和溶骨性骨病变。最近，一种仅限于颌面部骨骼的特殊形式的骨坏死被发现，尤其是在那些单独接受长期N-BP治疗和/或与侵入性牙科手术相关的患者中。由于骨转换重塑率高以维持机械功能，双膦酸盐几乎只在颌面部骨骼中蓄积。其发病机制以及为何常见于颌面部骨骼和固定的治疗策略仍不清楚。本研究的目的是通过回顾过去10年的文献，提高临床医生对N-BP相关颌面部骨骼骨坏死的认识。
