Shah S A A, Aslam A, Mirza A I, Ali S
Department of Oral & Maxillofacial Surgery, de'Montmorency College of Dentistry/Punjab Dental Hospital, Lahore, Pakistan.
J Ayub Med Coll Abbottabad. 2010 Jul-Sep;22(3):214-7.
Bisphosphonates are used widely for a variety of bone conditions, most notably intravenous bisphosphonate in the treatment of metastatic bone lesions and multiple myeloma and oral bisphosphonates for osteoporosis. Recently, a peculiar form of osteonecrosis limited to the jaws has been discovered especially with the use of intravenous bisphosphonates. We review briefly the mechanism of action of these drugs, the clinical features and staging of the disease, prevention strategies and management options.
双膦酸盐被广泛用于多种骨骼疾病，最显著的是静脉注射双膦酸盐用于治疗转移性骨病变和多发性骨髓瘤，口服双膦酸盐用于治疗骨质疏松症。最近，尤其是在使用静脉注射双膦酸盐时，发现了一种仅限于颌骨的特殊形式的骨坏死。我们简要回顾这些药物的作用机制、该疾病的临床特征和分期、预防策略及治疗选择。
